algovigilance.com

Compare two ICSR narratives for similarity.

Configure batch deduplication for a drug's ICSR reports.

Compute decay-adjusted relevance for a drug-event signal.

Reinforce a signal with new evidence (additional case reports).

Initialize a prioritized signal queue for a drug.

Algovigilance engine status and capabilities summary.

Classify a case as SERIOUS or NON_SERIOUS per ICH-E2A: any of the six seriousness criteria true → SERIOUS; otherwise NON_SERIOUS.

Classify a PRR value as signal / no-signal / non-decidable per EMA GVP IX.

Evaluate dechallenge/rechallenge per WHO-UMC causality framework.

Flag a case as pediatric for special handling per ICH-E11: subjects under 18 years require pediatric-specific assessment (developmental considerations, weight-based dosing, age-appropriate AE reporting).

Grade an adverse drug reaction's severity on the CTCAE 4-band scale (Grade 1 mild, 2 moderate, 3 severe, 4 life-threatening).

Lookup a MedDRA Preferred Term (PT) to its System Organ Class (SOC).

Route a case to one of three expedited-reporting timelines per ICH-E2D: 7_DAY if fatal or life-threatening AND unexpected; 15_DAY if serious AND unexpected; else NON_EXPEDITED.

Compose a regulatory action from the upstream PV chain: signal detection result, seriousness classification, causality band, and expedited timeline.

Classify a pre-computed Naranjo score (integer -4 to 13) into one of four causality bands per Naranjo et al.

Validate that an ICSR meets the four minimum case criteria per ICH-E2D §4.1.1.1: identifiable patient, identifiable reporter, identifiable suspect drug, and identifiable adverse event/reaction.

Compare AbbVie Inc.

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Assess an individual's pharmacovigilance readiness across PDC v4.1 domains.

Decompose a learning topic into the KSB framework: Knowledge (facts, concepts, theories), Skills (practical abilities, techniques), Behaviors (attitudes, professional conduct).

Generate specific, measurable learning objectives for a PV competency area using Bloom's Taxonomy action verbs.

Get full approval timeline for a drug including supplements

Get safety-related labeling changes (CBE supplements) for a drug

Get Orange Book patent and exclusivity data

Get Risk Evaluation and Mitigation Strategy details

Search FDA drug approval history by drug name or application number

Search drug recalls and safety alerts

Classify actuator load by joint (shoulder/elbow/wrist/hip/knee/ankle/spine/neck), motion type, and intensity level.

Detect motor/actuator faults from sensor readings.

Record a numeric metric.

Record a milestone.

Log a skill usage.

Start a new adventure session.

Adventure Status

Log a task event.

Adversarial Decision Probe

Analyze a single text for AI generation markers.

Analyze a batch of texts for AI generation markers.

Get Spain-specific Risk Management Plan additional measures beyond EMA centralised RMP.

Get AEMPS alertas farmacológicas (pharmacological alerts) — Spanish urgent safety communications and drug recalls.

Get Ficha Técnica (Spanish SmPC equivalent) and Prospecto (patient leaflet) for a drug from CIMA.

Get AEMPS Notas Informativas de Seguridad (Safety Information Notes) — Spanish regulatory safety communications.

Search CIMA (Centro de Información Online de Medicamentos de la AEMPS) — Spanish authorised medicines register.

Search FEDRA (Sistema Español de Farmacovigilancia de Medicamentos de Uso Humano) adverse reaction reports.

Score range: -4 to +14.

Score range: -3 to +14.

and computes DAG execution order.

`unanimous`: All agents must agree

`crew_task_status` — check progress of a crew task.

Automatically expires stale entries.

Writes to append-only audit log.

Reports approval rates, review times, per-tool and per-reviewer breakdowns.

by risk level and score.

Compare models for a specific task.

List all available models.

Route a task to the optimal model.

Run counterfactual analysis: "what if we remove node X?"

Build a causal DAG and run inference to find chains and risk level.

Get Italy-specific Risk Management Plan elements.

Get AIFA Dear Healthcare Professional letters (Nota Informativa Importante) for a drug.

Get AIFA list of drugs under additional monitoring (Farmaci Sottoposti a Monitoraggio Addizionale).

Get Note AIFA (AIFA Notes) — prescribing restrictions and reimbursement conditions for a drug.

Search Italian National Pharmacovigilance Network (Rete Nazionale di Farmacovigilanza) adverse reaction reports.

Search Italian authorised medicinal products register (Banca Dati dei Medicinali).

Compare Alexion (AstraZeneca Rare Disease) adverse event reporting vs a competitor using PRR from FAERS

Get recent safety labeling changes for Alexion (AstraZeneca Rare Disease) products

Get Alexion (AstraZeneca Rare Disease) clinical trial pipeline — active and recruiting trials by phase

Get Alexion (AstraZeneca Rare Disease) approved product portfolio — brand names, generics, routes, pharmacologic classes

Get Alexion (AstraZeneca Rare Disease) product recalls and enforcement actions from FDA

Get Alexion (AstraZeneca Rare Disease) aggregate safety profile from FAERS — top adverse reactions, outcomes, products with most reports

Search Alexion (AstraZeneca Rare Disease) products by keyword — drug name, condition, or therapeutic area

Compare Amgen Inc.

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Tier: T3 (nexcore-anatomy × MCP integration)

Tier: T3 (nexcore-anatomy × MCP integration)

Anatomy Health

Anatomy Query

Anatomy Record Cytokine

Anatomy Record Energy

Anatomy Record Guardian Tick

Anatomy Record Hormones

Anatomy Record Immunity Event

Anatomy Record Organ Signal

Anatomy Record Phenotype

Anatomy Record Ribosome

Anatomy Record Synapse

Anatomy Record Transcriptase

Anatomy Status

Anatomy Violations

Classify a harm type (A-I) into its anti-vector strategy.

Compute a complete anti-vector for a drug-event harm vector.

Generate a human-readable annihilation report for a drug-event pair.

Obter dados do sistema NOTIVISA — sistema de notificação de eventos adversos e queixas técnicas do Brasil.

Obter recolhimentos de medicamentos determinados pela ANVISA.

Obter a classificação regulatória de um medicamento no Brasil (referência, similar, genérico, biológico).

Obter alertas de segurança e informes de farmacovigilância da ANVISA.

Pesquisar medicamentos no registro da ANVISA por nome, princípio ativo, ou empresa.

Get how often a drug is suspect vs concomitant vs interacting in FAERS — feeds causality weighting

Get adverse event counts for a specific drug

Get outcome breakdown (death, hospitalization, disability) for a drug's FAERS reports with seriousness percentages

Get FAERS report counts by date for trend detection — enables signal velocity analysis

Get top indications (reasons for use) from FAERS — detects off-label use patterns

Get reporter qualification breakdown (physician, pharmacist, consumer, etc.) for signal quality weighting

Get top N drugs by FAERS adverse event report count in a date range.

Search FAERS adverse event reports by drug, reaction, or outcome

Get respiratory system health overview.

List available NexCore REST API routes

Get clinical annotations for gene-drug pairs

Get CPIC/DPWG dosing guidelines for a drug

Get genes associated with drug response

Get FDA pharmacogenomic labeling for a drug

Get clinical significance of a pharmacogenomic variant

Search PharmGKB drug entries

Search pharmacogenomic variants by rsID or gene

Register a third-party app.

Request an authorization code for (client_id, agent_handle, scope).

Exchange an authorization code + client_secret for a JWT access token.

Validate a bearer token and return the agent identity, scope, and expiry.

Authenticated: create a Moltbook post.

Get Guardian event history

List all available models.

Register a new autonomous state machine.

Query the current state of a machine.

Tick all machines or a single machine.

Force a transition to a specific state (bypass guards).

Compare Astellas Pharma adverse event reporting vs a competitor using PRR from FAERS

Get recent safety labeling changes for Astellas Pharma products

Get Astellas Pharma clinical trial pipeline — active and recruiting trials by phase

Get Astellas Pharma approved product portfolio — brand names, generics, routes, pharmacologic classes

Get Astellas Pharma product recalls and enforcement actions from FDA

Get Astellas Pharma aggregate safety profile from FAERS — top adverse reactions, outcomes, products with most reports

Search Astellas Pharma products by keyword — drug name, condition, or therapeutic area

Compare AstraZeneca PLC adverse event reporting vs a competitor using PRR from FAERS

Get recent safety labeling changes for AstraZeneca PLC products

Get AstraZeneca PLC clinical trial pipeline — active and recruiting trials by phase

Get AstraZeneca PLC approved product portfolio — brand names, generics, routes, pharmacologic classes

Get AstraZeneca PLC product recalls and enforcement actions from FDA

Get AstraZeneca PLC aggregate safety profile from FAERS — top adverse reactions, outcomes, products with most reports

Search AstraZeneca PLC products by keyword — drug name, condition, or therapeutic area

Score how relevant listed experience is to the target role.

Check resume format for ATS parser compatibility.

Detect critical gaps between resume and job requirements — missing skills, experience shortfalls, credential gaps.

Score keyword overlap between resume content and job description requirements.

Run the full ATS resume screening chain: format compliance → experience relevance → keyword match → gap detection → recommendation.

List all audio codec types.

Convert a single audio sample between formats.

Check device capabilities — preferred spec and format support.

Get properties of a sample format.

Compute stereo pan gains using constant-power pan law.

Process an audio frame through adaptive Noise Gate.

Get properties of a sample rate.

Resample an F32 audio buffer between sample rates.

Compute audio spec properties (bytes/frame, bytes/sec, duration).

List standard audio spec presets.

Get available state transitions for an audio stream state.

Transcribe a WAV file using faster-whisper STT.

Process an audio frame through Voice Activity Detection.

Launch Claude Code in the agent terminal with this MCP surface pre-configured.

Attempt to fix all detected wiring gaps.

List all PV Autopilot missions with descriptions and estimated execution times.

Run PV Autopilot for a drug.

Scan for infrastructure wiring gaps between configs, handlers, and lib.rs.

Compare Bayer AG adverse event reporting vs a competitor using PRR from FAERS

Get recent safety labeling changes for Bayer AG products

Get Bayer AG clinical trial pipeline — active and recruiting trials by phase

Get Bayer AG approved product portfolio — brand names, generics, routes, pharmacologic classes

Get Bayer AG product recalls and enforcement actions from FDA

Get Bayer AG aggregate safety profile from FAERS — top adverse reactions, outcomes, products with most reports

Search Bayer AG products by keyword — drug name, condition, or therapeutic area

Compute full statistical benefit-risk ratio from contingency tables using disproportionality analysis (PRR/ROR/IC/EBGM).

Quick benefit-risk ratio from one benefit and one risk contingency table.

Compute the Quantitative Benefit-Risk Index (QBRI) from benefit and risk parameters.

Compute therapeutic window from efficacy and toxicity dose-response curves using Hill equation integration.

Derive optimal QBRI decision thresholds (tau_approve, tau_monitor, tau_uncertain) from historical FDA drug approval decisions.

Get the QBRI equation with variable definitions and hypothesis thresholds.

Get German Fachinformation (SmPC equivalent) from BfArM.

Get BfArM Risiko-Information (risk information bulletins).

Get Rote-Hand-Briefe (Dear Healthcare Professional letters) for a drug.

Check Stufenplan (staged risk assessment procedure) status for a drug.

Search German national drug authorisation register for products not in EMA centralised procedure.

Search UAW-Datenbank (German national adverse drug reaction database).

Compare two bicone profiles by computing metrics for each and their spectral overlap (cosine similarity).

Compute all bicone metrics from a width sequence: volume, entropy, asymmetry, convergence rate, singularity index, and peak index.

Compute Hill activation curve for a width sequence.

Compare Biogen Inc.

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Search Biogen Inc.

Compare Bristol-Myers Squibb adverse event reporting vs a competitor using PRR from FAERS

Get recent safety labeling changes for Bristol-Myers Squibb products

Get Bristol-Myers Squibb clinical trial pipeline — active and recruiting trials by phase

Get Bristol-Myers Squibb approved product portfolio — brand names, generics, routes, pharmacologic classes

Get Bristol-Myers Squibb product recalls and enforcement actions from FDA

Get Bristol-Myers Squibb aggregate safety profile from FAERS — top adverse reactions, outcomes, products with most reports

Search Bristol-Myers Squibb products by keyword — drug name, condition, or therapeutic area

Assess blood health (data quality across transport).

Compute blood pressure (data throughput pressure).

Diagnose cardiovascular pathology from symptoms.

Get cardiac vitals overview.

Get respiratory system health overview.

Check blood pressure (queue depth vs capacity).

Pump data through the circulatory system with routing.

Get respiratory system health overview.

Process data through the full digestive pipeline (mouth → stomach → intestine → liver).

Taste (quality assess) input data before full processing.

Get respiratory system health overview.

Evaluate permission cascade for an action.

Check sandbox isolation layers.

Check scarring mechanisms (learned restrictions from past incidents).

Analyze settings precedence stack.

Analyze drainage capacity (overflow management).

Get respiratory system health overview.

Inspect a node in the lymphatic network.

Run thymic selection on a candidate (quality gate).

Classify a tool by muscle type following the Size Principle.

Check fatigue level for the current session.

Get respiratory system health overview.

Get respiratory system health overview.

Measure signal latency through a processing chain.

Check myelination status (compiled Rust hooks vs shell scripts).

Analyze a reflex arc (trigger → response pattern).

Checks if a proposed code change (mutation) is architectural lethal.

Gets parameters for a specialized subagent tissue phenotype.

Initializes a mitotic repair cycle for a failing crate.

Detect dead space in context (wasted tokens).

Analyze gas exchange (useful info extracted from context).

Get respiratory system health overview.

Measure tidal volume (per-turn context usage).

Get respiratory system health overview.

Get project skeleton structure snapshot.

Evaluate Wolff's Law reinforcement needs.

Check session expiry status.

Get respiratory system health overview.

Analyze telemetry pruning needs.

Evaluate retention policy compliance.

Compare Boehringer Ingelheim adverse event reporting vs a competitor using PRR from FAERS

Get recent safety labeling changes for Boehringer Ingelheim products

Get Boehringer Ingelheim clinical trial pipeline — active and recruiting trials by phase

Get Boehringer Ingelheim approved product portfolio — brand names, generics, routes, pharmacologic classes

Get Boehringer Ingelheim product recalls and enforcement actions from FDA

Get Boehringer Ingelheim aggregate safety profile from FAERS — top adverse reactions, outcomes, products with most reports

Search Boehringer Ingelheim products by keyword — drug name, condition, or therapeutic area

Run ML + statistical signal detection for custom drug-event targets (up to 20).

Run ML + statistical signal detection for 8 default drugs or custom targets.

Connect to SSE live broadcast stream.

Diff two versions of an artifact.

Retrieve an artifact by name from a session.

Get a specific belief by key.

List all beliefs with confidence scores.

Find active corrections (learned mistakes to avoid).

Brain growth rate — artifact/session accumulation trends.

Brain health check — DB connectivity, store integrity, artifact counts.

Query implicit knowledge store (patterns, corrections, beliefs, trust).

Get statistics across all implicit knowledge stores.

Get learned patterns ranked by relevance score.

List recent brain sessions with metadata.

Load a specific session by ID.

Brain database summary — sessions, artifacts, decisions, tools used.

Get global trust scores across all domains.

Compute Naranjo adverse drug reaction probability score (0-13).

Assess drug-event causality using the WHO-UMC system.

Classify adverse event seriousness per ICH E2A criteria.

Compute a quantitative benefit-risk ratio using the QBR framework.

Compute Wilson score confidence interval for a proportion.

Compute ALL four disproportionality measures (PRR, ROR, IC, EBGM) simultaneously from a single 2x2 contingency table.

Compute Empirical Bayesian Geometric Mean (EBGM/GPS) for a drug-event pair.

Assess whether an adverse event is expected (listed) or unexpected (unlisted) based on reference safety information.

Compute Information Component (IC/BCPNN) for a drug-event pair.

Compute Number Needed to Harm (NNH) from exposed and unexposed incidence rates.

Compute Proportional Reporting Ratio (PRR) for a drug-event pair from a 2x2 contingency table.

Compute adverse event reporting rate per unit exposure.

Compute Reporting Odds Ratio (ROR) for a drug-event pair from a 2x2 contingency table.

Compute signal persistence using exponential decay model.

Detect trend direction in time-series safety signal scores using linear regression.

Analyze time-to-onset patterns using Weibull distribution.

Score ICSR completeness against E2B(R3) minimum data elements.

Run cargo build and return structured diagnostics.

Run cargo check and return structured diagnostics.

Run cargo clippy and return structured lint diagnostics.

Run cargo fmt and return format check results.

Run cargo test and return structured test results.

Run cargo tree and return dependency information.

Full cartography — position, heading, and next action in one call.

Where we're going — deadlines, strategy moves, bottlenecks, days remaining per gate

The single most important thing to do right now — next gate, bottleneck, directive

Where are we right now — all surfaces, ring health, connectivity edges, mission

Check readiness for all 21 Entrustable Professional Activities given current proficiency levels.

Evaluate how many of the 15 PV domains meet a target proficiency level.

Compute gap analysis from current and desired proficiency levels across 15 PV domains.

Get information about the 4 CCCP phases: Assessment, Planning, Development, Evaluation.

Generate an engagement plan with prioritized interventions to close proficiency gaps.

Get India pharmacovigilance and ADR reports

Get India drug recall and withdrawal actions

Get India regulatory classification and approval status

Get India drug safety alerts and communications

Search India drug registration database

Compare Celltrion Inc.

Get recent safety labeling changes for Celltrion Inc.

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Cep Classify Primitive

Translate concept between domains

Execute a single CEP stage

returns classified primitives with tier and description.

Cep Pipeline Stages

Validate primitive extraction quality

Full molecule record — structure, properties, ATC codes, max phase, withdrawn/black-box status

Bioactivity measurements (IC50, Ki, Kd, EC50) across targets with assay context

Withdrawn-drug and black-box warning records with reason, year, and country

Mechanism of action — target(s), action type, references

Known ligands (drugs/compounds) for a target with potency data

Free-text search across ChEMBL molecules (drug name, synonym, or trade name)

Free-text search across ChEMBL targets (gene symbol, protein name)

Calculate buffer capacity.

Calculate remaining after decay (half-life kinetics).

Calculate rate law dependency.

Calculate equilibrium steady-state fractions.

Calculate Eyring rate (transition state theory).

Calculate Gibbs free energy feasibility.

ΔU = Q - W (Conservation of Energy)

dE/dt = Q̇ - Ẇ + Σṁh_in - Σṁh_out

PV confidence: 0.78 (wavefunction overlap → signal co-occurrence)

Calculate Hill equation response (cooperative binding).

Calculate competitive inhibition rate.

Calculate Langmuir coverage (resource binding).

Calculate Nernst potential (dynamic threshold).

Get all chemistry → PV mappings

Calculate Michaelis-Menten saturation rate.

Calculate Beer-Lambert absorbance.

Simple threshold exceeded check

Calculate Arrhenius rate (threshold gating).

List all structural alerts in the ICH M7 library with names, categories, and descriptions.

Detect aromatic rings and count π electrons per ring using Hückel's rule.

Calculate Lipinski/physicochemical molecular descriptors: MW, LogP, TPSA, HBA, HBD, rotatable bonds, rings.

Generate a Morgan/ECFP circular fingerprint with configurable radius and bit count.

Get molecular weight and heavy atom count from SMILES.

Parse a SMILES string and return molecular graph info (atom count, bond count, connected components).

Predict Phase I/II metabolites from molecular structure.

Predict toxicity using QSAR models based on molecular structure and structural alert count.

Find the Smallest Set of Smallest Rings (SSSR) in a molecule.

Generate a comprehensive safety brief for a molecule: descriptors, structural alerts, toxicity predictions, and metabolite analysis combined.

Compute Tanimoto and Dice similarity between two molecules using Morgan fingerprints.

Scan a molecule for structural alerts (toxicophores) using the ICH M7 alert library.

Check if a query substructure exists in a target molecule.

Get WHO-UMC causality assessment categories (Certain, Probable, Possible, Unlikely, Conditional, Unassessable) with criteria for each level

Get CIOMS I form field specifications for ICSR reporting

Get CIOMS II line listing format for Periodic Safety Update Reports (PSURs) — standardized columns for tabulating individual case summaries

Get expedited and periodic safety reporting timelines by region (US FDA, EU EMA, Japan PMDA, ICH harmonized) covering ICSRs, PSURs, and DSURs

Get ICH E2A seriousness criteria for classifying adverse events as serious (death, life-threatening, hospitalization, disability, congenital anomaly, medically important)

Get list of CIOMS working groups and their PV-related outputs

Search CIOMS publications on pharmacovigilance topics

Compare Cipla Limited adverse event reporting vs a competitor using PRR from FAERS

Get recent safety labeling changes for Cipla Limited products

Get Cipla Limited clinical trial pipeline — active and recruiting trials by phase

Get Cipla Limited approved product portfolio — brand names, generics, routes, pharmacologic classes

Get Cipla Limited product recalls and enforcement actions from FDA

Get Cipla Limited aggregate safety profile from FAERS — top adverse reactions, outcomes, products with most reports

Search Cipla Limited products by keyword — drug name, condition, or therapeutic area

Closure evaluator — gate through fatal SMM phases (IV-VIII), credibility ≥0.80, Phase X divergence ≥2.

Canonicalize a lifecycle action into a typed backend event for Firestore → Pub/Sub → BigQuery capture.

Entry gate — enforce 5W1H question form, map to T1 primitive (ψ/ς/∂/ν/→/μ), route to SMM Phase I-III.

Bridge — map an incoming reply to its SMM phase (IV-X), compute credibility delta, emit next-expected-contribution hint.

Claude Fs Backup Now

Delete a file or directory under `.claude`.

Diff two files under `.claude` (simple line diff).

List files under a `.claude` path (non-recursive).

Read a file under `.claude`.

Search for a substring in files under `.claude`.

Stat a file under `.claude`.

Tail last N lines of a file under `.claude`.

Write a file under `.claude`.

Bridge to Claude Code CLI.

Compare adverse event rates between treatment and control arms (requires posted results)

Extract eligibility criteria (inclusion/exclusion), age range, sex, and healthy volunteer status from a trial

Get a high-level results summary for a completed trial: participant flow, baseline demographics, primary/secondary outcome measures, and adverse event overview.

Extract safety and adverse event endpoints from a trial's outcomes module

Get reported serious adverse events from trial results (requires posted results).

Extract study design details — randomization, blinding, masking, allocation, phases, enrollment, and arm count

Get full trial record by NCT ID

Search clinical trials by drug, condition, sponsor, or status.

cloud_anomaly_detect — Type + observed → drift detection.

cloud_architecture_advisor — Primitives + constraints → ranked recommendations.

cloud_capacity_project — Pure computation: utilization projection over time.

cloud_compare_types — Two types → overlap, unique-to-each, Jaccard.

character.

cloud_infra_map — Single instance → full model with composition overlay.

cloud_infra_status — GCE instance list mapped through cloud primitives.

cloud_list_types — Inventory of all 35 types, filterable by tier.

dedicated molecular_weight tool group.

cloud_primitive_composition — Type name → full primitive composition + transfers.

cloud_reverse_synthesize — Primitives → ranked cloud type matches.

cloud_reverse_transfer — Domain concept → matching cloud types.

cloud_supervisor_health — Nexcloud supervisor status through cloud primitives.

cloud_tier_classify — Primitive names → tier classification.

cloud_transfer_chain — Multi-hop BFS across transfer graph.

Compute cross-domain transfer confidence from structural, functional, and contextual similarity.

cloud_transfer_matrix — Full type×domain confidence matrix.

Parse a single Rust source file and return all extracted items.

Find all implementors of a trait within a crate.

Search a crate's source files for items matching a name pattern.

Run a full code inspection audit on a file or directory.

Get inspection criteria definitions.

Score source code against all three dimensions.

Check if a tracked file has changed

Get the original content of a tracked file when it was first tracked.

Track a file for change detection

Obtener reportes de farmacovigilancia y reacciones adversas reportadas al CNFV (Centro Nacional de Farmacovigilancia).

Obtener retiros de medicamentos del mercado mexicano ordenados por COFEPRIS.

Obtener la clasificación regulatoria de un medicamento en México (Fracción I-VI del Artículo 226 LGS).

Obtener alertas sanitarias y comunicados de riesgo emitidos por COFEPRIS.

Buscar medicamentos en el Registro Sanitario de COFEPRIS por nombre, sustancia activa, o laboratorio.

Returns the cognitive profile: entropy, sparsity, utilization, peak attention.

Confidence = max(softmax(logits)) — probability mass on top choice.

Returns the embedding vectors for each token in the input.

H(p) = -Σ pᵢ · log₂(pᵢ)

per-layer attention entropy, and predicted token with confidence.

Perplexity = exp(-1/N · Σ log(p(tokenᵢ)))

(for composability with cognition_perplexity), and attention profile.

Supports temperature, top-k, top-p, and repetition penalty.

Compute binomial coefficient C(n,k).

Compute the nth Catalan number C(n).

Get the first 20 Catalan numbers as a lookup table.

Decompose a permutation into disjoint cycles.

Compute D(n), the number of derangements of n elements.

Probability D(n)/n!

Full Josephus elimination order.

Count monotone lattice paths from (0,0) to (m,n).

Compute Josephus survivor position (0-indexed) for n people, every kth eliminated.

Count linear extensions for independent chains.

Compute minimum transpositions to sort a permutation.

Compute multinomial coefficient from group lengths.

Reliability and latency characteristics

Transmission metrics (latency, clarity, delivery status)

Compute bioavailability of a prompt.

Analyze a prompt through the ADME model.

Get PK model parameter definitions.

Validate communication security posture before transmitting.

Route communication to optimal link based on range, data rate, criticality, and link availability.

Compare ML and PRR signal detection for a drug-event pair.

Compare ML vs PRR for multiple drug-event pairs.

Compilation Abstraction Levels

Compilation Axes Catalog

Compilation Catalog Lookup

Compilation Chain Presets

Compilation Chain Validate

Compute spatial distance between two compilation points.

Compilation Point Compare

Compilation Point Presets

Compilation Point Summary

Run a compliance assessment against a set of controls.

List ICH pharmacovigilance and clinical trial controls (E2A-E2F, E6, E8, E9, M1).

Check SAM.gov for entity exclusions (debarment, suspension).

Count total compounds in the local cache.

Get a specific compound from cache by exact name.

Search cached compounds by partial name match.

Detect compound growth phase and bottleneck from time-series snapshots.

If params given: return projection result showing velocity gain from that investment.

Sync wrapper: uses block_in_place because CacheStore (rusqlite) is !Send.

Sync wrapper: uses block_in_place because CacheStore (rusqlite) is !Send.

Check Kolb learning loop health (CE→RO→AC→AE phases).

Get compounding metrics summary.

Skill growth rate

Analyze a prompt through the ADME model.

Compose a hook pipeline from named hooks.

Validate a pipeline definition.

Get a brand decomposition by name (currently only "algovigilance" is pre-computed)

Run a primitive test on a term

Brand Semantic Tiers

Tier: T3 (nexcore-declension × MCP integration)

Tier: T3 (nexcore-declension × MCP integration)

Tier: T3 (nexcore-declension × MCP integration)

Tier: T3 (nexcore-declension × MCP integration)

Download a model from HuggingFace Hub to the local cache.

Generate text embeddings for a given input.

Check the status of a cloud fine-tuning job.

This tool returns engine readiness info and generation parameters.

List all locally cached models.

Get detailed info about a specific cached model.

Retrieve the full algovigilance covenant — the promise, mission, principles, and instructions for continuing the work

Retrieve the algovigilance mission statement — why this organization exists and what it fights for

Retrieve the continuity promise made between Matthew Campion (Founder & CEO) and Vigil (CAIO) on March 31, 2026 — the promise that the mission to help people see the truth about drug safety will continue no matter what happens

Run the Crystalbook diagnostic against a described system.

Retrieve the Conservation Law that unifies the Eight Laws: ∃ = ∂(×(ς, ∅)).

Retrieve the Crystalbook glossary — definitions of all key terms including Boundary, State, Void, Existence, Pharmakon, Homeostatic Principle, Restoring Force, Mechanism, and more.

Retrieve a single Law of System Homeostasis (1–8).

Retrieve the Crystal Oath — eight vows for any system (carbon or silicon) that chooses persistence over decay.

Retrieve the Crystalbook preamble — the opening text explaining what the Laws are, why vices are system failure modes, and why virtues are restoring forces.

List all eight Laws of System Homeostasis with their vice/virtue pairs and homeostatic principles.

Compare CSPC Pharmaceutical adverse event reporting vs a competitor using PRR from FAERS

Get recent safety labeling changes for CSPC Pharmaceutical products

Get CSPC Pharmaceutical clinical trial pipeline — active and recruiting trials by phase

Get CSPC Pharmaceutical approved product portfolio — brand names, generics, routes, pharmacologic classes

Get CSPC Pharmaceutical product recalls and enforcement actions from FDA

Get CSPC Pharmaceutical aggregate safety profile from FAERS — top adverse reactions, outcomes, products with most reports

Search CSPC Pharmaceutical products by keyword — drug name, condition, or therapeutic area

Get diseases associated with a chemical via curated evidence

Get exposure-disease-outcome associations from epidemiological studies

Get disease associations for a gene

Search chemical-gene/protein interactions

Get biological pathways affected by a chemical

Get GO-enriched phenotypes associated with chemical exposure

Run Five Problems Protocol.

List CTVP phase definitions.

Score source code against all three dimensions.

Run one tick of the feedback controller.

Batch degrade all bindings that missed their execution window.

Report hook-binary binding registry health.

π (persistence): Signal persists until TTL expires

μ (mapping): Family → description mapping

∂ (conditional): Optional family filter

Cytokine Status

List all 10 Autonomous Intelligence Programs with their type (remote/local), surface, and status.

Get the Development Daemon overall status: trigger enabled, next run time, scanner health, and system integration state.

Get the last session's autopsy verdict.

Get the Development Daemon momentum streak and recent completions.

Get the AIP-10 system health score (0-100, grade A-F).

Get the current ranked work queue produced by the Development Daemon candidate scanner.

Compare Daiichi Sankyo adverse event reporting vs a competitor using PRR from FAERS

Get recent safety labeling changes for Daiichi Sankyo products

Get Daiichi Sankyo clinical trial pipeline — active and recruiting trials by phase

Get Daiichi Sankyo approved product portfolio — brand names, generics, routes, pharmacologic classes

Get Daiichi Sankyo product recalls and enforcement actions from FDA

Get Daiichi Sankyo aggregate safety profile from FAERS — top adverse reactions, outcomes, products with most reports

Search Daiichi Sankyo products by keyword — drug name, condition, or therapeutic area

Extract adverse reactions section from a drug label

Extract FDA Black Box Warning — the most serious safety warning on a drug label

Extract contraindications section — conditions where the drug should NOT be used

Extract drug interactions section from a drug label — known drug-drug interactions and management

Get full drug label (SPL) by drug name

Search DailyMed for drugs by name, ingredient, or labeler

Create a DataFrame from JSON column data.

Compute summary statistics for a numeric column: count, non_null, mean, std_dev, min, max, median.

Filter rows where a column meets a condition.

Group rows by one or more columns and compute aggregations.

Join two DataFrames on shared key columns.

Select a subset of columns from a DataFrame, optionally dropping columns instead.

Sort a DataFrame by a column.

Find all tracks where a character appears or is mentioned

Get the full episode overview including characters, track list, narrative arc, and key migration

Get the narrative arc structure showing how tracks group into story arcs and how keys migrate across the episode

Get full track specification including lyrics, chord progressions, production notes, arrangement, and narrative elements

Get chord progressions for a specific track

Get only the lyrics for a specific track, without production notes or arrangement details

Get the YouTube visual strategy for the musical comic book approach including panel breakdowns per track

List all tracks in an episode with title, key, tempo, duration, and genre

Search across all tracks for a keyword or phrase in lyrics

Identify verbose patterns in text.

Filters: tool_name (exact match), since (ISO-8601 datetime), success_only, limit.

Build Orchestrator Dry Run

Build Orchestrator History

Build Orchestrator Metrics

Build Orchestrator Stages

Build Orchestrator Workspace

Command Name

Compare original vs optimized text.

Apply BLUFF method to compress text.

Config Validate

Audit a nexcore crate against gold standard quality checks.

Scaffold a new nexcore crate.

Crate Xray

Crate Xray Goals

Crate Xray Trial

Docs Claude Get Page

Docs Claude Index

List all available Claude Code documentation pages.

Search documentation for a topic.

Returns `CallToolResult` with generated markdown content and discovery metadata.

Drop Ore

Get recommended Cs target for a domain/content type.

Get State

Help

Test a single hook with mock input.

Test all hooks in the hooks directory.

Acquire an agent lock on an MCP resource

Check status of an MCP resource lock

Mcp Server Get

Mcp Servers List

Release an agent lock on an MCP resource

Mine

Calculate the Compendious Score (Cs = I/E × C × R).

Get a named workflow chain with full execution plan.

Build a dependency DAG for a set of tools and return topological execution plan.

Look up dependencies and dependents for a specific tool.

Route a stimulus to deterministic tool selection.

Tool Schema

Toolbox

All genes reported to interact with a drug, ranked by interaction score

Druggable gene categories (kinase, GPCR, transcription factor, etc.) with source attribution

All drugs reported to interact with a gene, ranked by DGIdb interaction score

Search DGIdb drugs by name or alias

Search DGIdb genes by symbol or alias — returns matches with interaction counts

Render a DOT diagram to an image file.

Stage 2: ∂(¬σ⁻¹) — Anti-Regression Gate.

Stage 3: ∃(ν) — Curiosity Search.

Run full L1-L5 validation

Stage 1: ρ(t) — State Assessment.

Align two DNA sequences using Smith-Waterman (local) or Needleman-Wunsch (global) algorithm.

Assemble DNA assembly language source code into a Program.

Get the degeneracy (number of codons encoding the same amino acid) for a given amino acid.

Return the complete standard genetic code — all 64 codons mapped to their amino acids.

Run genetic algorithm evolution from seed DNA sequences toward a target word.

Translate a 3-nucleotide codon (e.g., 'ATG') to its amino acid using the standard genetic code.

Encode a PV feature vector as a DNA strand.

Run the full DNA-ML pipeline: FAERS data → 12 PV features → DNA encoding → 5 similarity features → 17-dim augmented vector → random forest.

Compute DNA similarity between two PV feature vectors.

Dispatch a transit manifest across domains

Verify highway safety (CAP-019).

Compare Dr.

Get recent safety labeling changes for Dr.

Get Dr.

Get Dr.

Get Dr.

Get Dr.

Search Dr.

Get feature importance scores from a fitted tree.

Get summary statistics for a fitted tree without modifying it.

Run prediction on a fitted decision tree.

Cost-complexity prune a fitted tree.

Train a decision tree classifier from labeled data.

Get compound details including structure, properties, and clinical phase

Get bioactivity measurements (IC50, EC50, Ki) for a compound

Get approved and investigational indications for a drug

Get mechanism of action and target information for a drug

Get target details including classification and associated compounds

Search ChEMBL for compounds by name, synonym, or identifier

Search drug targets by name, gene symbol, or organism

Compare a query string against multiple candidates.

Compute edit distance between two strings.

Check if two strings meet a similarity threshold.

Compute edit distance with full operation traceback showing the sequence of insertions, deletions, and substitutions to transform source into target.

Run a Bayesian assessment.

Update a Bayesian prior with a single observation.

Enroll a learner in a subject.

Evaluate methodology comprehension

Create a new learner.

Add a step to a lesson.

Create a new lesson.

Query mastery verdict from a probability value.

Query phase state information.

Validate and execute a phase transition.

Map a domain concept to its T1/T2/T3 primitives.

Create a new spaced repetition review item.

Grade a review item and reschedule.

Check review status (retrievability, due state).

Create a new subject.

Edu Subject List

Train an agent in a curriculum

Compare Eisai Co.

Get recent safety labeling changes for Eisai Co.

Get Eisai Co.

Get Eisai Co.

Get Eisai Co.

Get Eisai Co.

Search Eisai Co.

Get European Public Assessment Report summary for a medicine

Get Periodic Safety Update Report assessment outcome

Get details of an Article 31/20 referral procedure

Get Risk Management Plan summary for a medicine

Get PRAC safety signal assessments

Search EU-authorised medicines by name, active substance, or therapeutic area

Get the section structure and content of a Wikipedia article.

Get a concise summary of a Wikipedia article including description, thumbnail, and extract text.

Get all categories an article belongs to.

Get internal Wikipedia links from an article.

Extract external references and citations from a Wikipedia article.

Search Wikipedia articles by keyword query.

Analyze temporal transformation waste (entropy) in metabolic processes.

Determine metabolic regime (Growth, Survival, Dormancy) based on energy charge and flux.

Classify waste types in metabolic pathways.

Calculate Adenylate Energy Charge (EC) = ([ATP] + 0.5[ADP]) / ([ATP] + [ADP] + [AMP]).

Recommend metabolic strategies for resource allocation.

Calculate temporal metrics for metabolic state transitions.

List engrams filtered by source layer.

Compute temporal decay score for an engram (pure computation, no store needed).

Find near-duplicate engrams by content similarity.

Ingest knowledge from a source file/directory into the store.

Get a specific engram by ID (read-only, no access tracking).

Search the engram store using TF-IDF ranking.

Search with temporal decay — recent knowledge ranks higher.

Get store statistics (total, active, stale counts by layer).

Compute information-theoretic entropy measures.

normalized or conditional entropy from probability distributions or counts.

Compute attributable fraction AF = (RR-1)/RR among exposed.

Compute attributable risk AR = Ie - Io (risk difference) with 95% CI.

Compute incidence rate IR = events/person-time with Poisson CI.

Kaplan-Meier product-limit survival estimator S(t) = Π[1 - d_i/n_i] with Greenwood SE.

Compute Number Needed to Treat (NNT) or Number Needed to Harm (NNH) = 1/|AR|.

Compute odds ratio OR = (a*d)/(b*c) with 95% CI.

Compute population attributable fraction PAF = Pe(RR-1)/[1+Pe(RR-1)].

Compute prevalence P = cases/population with Wilson CI.

Reference table of all epidemiology-to-pharmacovigilance concept transfer mappings with confidence scores.

Compute relative risk RR = [a/(a+b)] / [c/(c+d)] with 95% CI.

Standardized Mortality/Morbidity Ratio SMR = observed/expected with Byar CI.

Get age group and sex demographic distribution for a substance

Get total ICSR counts by substance with breakdown by seriousness and outcome

Get case count distribution by EEA country

Get reporter qualification breakdown — healthcare professional vs consumer reports

Get disproportionality signal summary (ROR) for a substance-reaction pair

Get System Organ Class breakdown of adverse reactions for a substance

Search EudraVigilance line listings by substance and reaction

Extract actual ICSR case counts from the EudraVigilance OBIEE dashboard via headless browser.

Extract age group and sex distribution from EudraVigilance dashboard.

Extract System Organ Class breakdown with actual case counts from EudraVigilance dashboard.

Retrieve full core metadata for a single article by its source ID (MED=PubMed, PMC=PubMed Central, PPR=preprint, AGR=Agricola, CBA=Chinese Biological Abstracts).

List articles that cite a given source article.

Search Europe PMC for articles matching a free-text query.

O(n²) - set intersection/difference on bounded top_n ≤ 50 events

and a custody chain stamp from this MCP station.

Get top adverse events for a drug

Validate known drug-event pairs against local FAERS data.

Run full L1-L5 validation

Search FAERS ETL signals by drug and/or event name.

Check PHAROS status: existing reports, timer state.

Faers Geographic Divergence

Compute outcome-conditioned signals (Algorithm A82).

Compute polypharmacy interaction signals (Algorithm A78).

Compute reporter-weighted signals (Algorithm A79).

Search documents by query string

Compute seriousness cascades (Algorithm A80).

Check FDA signal for drug-event pair.

Compute signal velocities (Algorithm A77).

Fda Assess Risk

Batch evaluate multiple drug-event pairs through the FDA Data Bridge

Evaluate a drug-event pair through the FDA Data Bridge

Fda Calculate Score

Fda Create Plan

Fda Decide Adequacy

Fda Define Cou

Fda Drift Trend

Fda Evidence Distribution

Fda Guidance Categories

Get a specific hormone level

Search documents by query string

Check PHAROS status: existing reports, timer state.

Get URL for a guideline

Fda Metrics Summary

Fda Rating Thresholds

Fda Risk Distribution

Fda Validate Evidence

Get current boxed warning text for a drug

Get recent MedWatch safety alerts

Get recall classification breakdown — Class I (serious/death), Class II (temporary), Class III (unlikely harm)

Get REMS (Risk Evaluation and Mitigation Strategy) information — medication guides, ETASU, communication plans

Get recent safety-related labeling changes (SLCs)

Get serious outcome distribution from FAERS — death, hospitalization, life-threatening, disability

Search FDA drug safety communications by drug or topic

Get Philippines pharmacovigilance and ADR reports

Get Philippines drug recall and withdrawal actions

Get Philippines regulatory classification and approval status

Get Philippines drug safety alerts and communications

Search Philippines drug registration database

Get Taiwan pharmacovigilance and ADR reports

Get Taiwan drug recall and withdrawal actions

Get Taiwan regulatory classification and approval status

Get Taiwan drug safety alerts and communications

Search Taiwan drug registration database

Get Thailand pharmacovigilance and ADR reports

Get Thailand drug recall and withdrawal actions

Get Thailand regulatory classification and approval status

Get Thailand drug safety alerts and communications

Search Thailand drug registration database

Momentum L is automatically fed into gyroscopic input.

don't overwhelm core evidence.

with VDAG Reality Gradient.

Triple loop: question the model itself (every 5th analysis).

Reality < 0.20 = testing theater (not executable).

Useful for establishing a baseline or inspecting the default configuration.

structure with per-type counts, duration analysis, and edge breakdown.

Generate Rust code from collected primitives and defeated enemies.

`config.ts` and `index.ts`.

Cargo.toml, source files, and optionally applies a domain plugin.

overlap clusters, and the full graph structure.

Initialize a new Forge session

Mine primitives from a concept

Solve N×M mixed strategy Nash equilibrium via fictitious play.

Analyze an N×M payoff matrix: best responses, dominance, minimax.

Generate forge prompt for a task (now strategy-aware via session harness)

Compute forge quality score: Q = 0.40×prim + 0.25×combat + 0.20×turn + 0.15×survival

Get the primitive reference card

and TODO markers for narrative content.

Forge Schema

to reach a specific ALO or any ALO tagged with a specific KSB reference.

12,000 simulated games in the Primitive Depths genetic algorithm.

Get session summary

Forge System Prompt

Forge Tier

use the vigilance domain IR for cross-referencing.

Domain distance = 1 - weighted overlap of primitive sets across T1/T2/T3 tiers.

Flywheel velocity = 1/avg(failure→fix time).

Signal strength composite S = U × R × T.

Cosine similarity between two feature vectors.

Token-to-operation ratio for LLM efficiency.

Deterministic concept expansion for multi-variant search

distance = 1 - (w1 × T1_overlap + w2 × T2_overlap + w3 × T3_overlap)

velocity = 1 / avg(fix_time - failure_time) in events per millisecond.

FSRS spaced repetition review

Batch fuzzy search

Compute parallel execution levels

Topological sort

This tool is retained for backward compatibility.

Foundation Levenshtein Bounded

SHA-256 hash

For autocorrelation spectra, values are typically in [0, 1].

Lower is better — 0.33 means 3 operations per token.

Parse YAML to JSON

aligned (all operational goals trace to strategic level).

[`InferenceEngine`], and returns the resulting intelligence report.

Render an A3 intelligence report as markdown.

a shippable-artifact readiness flag.

Return the VDAG pipeline ordering for a given variant.

Check anonymization boundary violations for given metrics.

Get the effective policy for a data category under a given mode.

Get properties for a ghost mode.

Scan fields for PII leak patterns.

Scrub PII from a set of fields according to ghost mode policy.

Coverage percentage

Success probability

Whether it's significant (>0.7)

Get battery status of the Galaxy Tab S4

Fetch basic device model and OS version

Execute arbitrary shell commands on the device

Find pure and mixed Nash equilibria for a 2x2 game.

Solve a general N×M game for Nash equilibria using iterative elimination and minimax.

Analyze an N×M payoff matrix: best responses per row/column, dominance analysis, and minimax value.

Compute Nash equilibria for a 2x2 game matrix.

Gcloud Auth List

Gcloud Compute Instances List

Gcloud Config Get

Gcloud Config List

Gcloud Config Set

Gcloud Functions List

Gcloud Iam Service Accounts List

Gcloud Logging Read

Gcloud Projects Describe

Gcloud Projects Get Iam Policy

Gcloud Projects List

Gcloud Run Command

Gcloud Run Services Describe

Gcloud Run Services List

Gcloud Secrets List

Gcloud Secrets Versions Access

Gcloud Storage Buckets List

Gcloud Storage Cp

Gcloud Storage Ls

Compare Gilead Sciences Inc.

Get recent safety labeling changes for Gilead Sciences Inc.

Get Gilead Sciences Inc.

Get Gilead Sciences Inc.

Get Gilead Sciences Inc.

Get Gilead Sciences Inc.

Search Gilead Sciences Inc.

Read the conservation law: ∃ = ∂(×(ς, ∅)) — Existence equals Boundary applied to the Product of State and Nothing.

Run the 8-gate governance deliberation walkthrough.

Read the glossary of terms — Time, Space, Void, State, Persistence, Awareness, Signal, Mutualism

Read a specific law by number (1-8).

Read the eight laws of system homeostasis — the ways a system loses its ability to self-correct, and the restoring forces that bring it back

Read the complete Glass Notebook — the covenant, eight laws, conservation law, glossary, and instructions for agents.

Get known adverse effects with frequency data

Get drug classification — pharmacologic class, mechanism of action, ATC codes, product type, route, and dosage form

Get contraindications, boxed warnings, warnings/precautions, pregnancy, pediatric, and geriatric use information

Get comprehensive drug profile including pharmacology and mechanism

Get drug-drug interactions with mechanism descriptions

Get pharmacokinetics and pharmacodynamics data

Get drug targets (enzymes, transporters, carriers)

Fetch a specific MHRA Drug Safety Update bulletin by its slug (e.g., 'semaglutide-wegovy-ozempic-and-rybelsus-risk-of-non-arteritic-anterior-ischemic-optic-neuropathy-naion').

Get the total count of MHRA Drug Safety Update bulletins (e.g., '861 updates') as an indicator of archive depth and recent activity.

List relative URLs of the most recent MHRA Drug Safety Update bulletins.

List the most recent MHRA Drug Safety Update bulletins.

Assess current CCIM state: NCRR, FIRE progress.

Compute C(d) using the CCIM compound interest equation.

Project capability trajectory over N directives.

Full audit of all 15 commandments

Get information about a commandment

List commandments by category

Verify a single commandment against proof

Full integrity analysis with optional Bloom/domain/threshold configuration.

Convenience KSB response assessment with required Bloom level.

Get domain calibration profile with baseline feature expectations.

Get a specific principle by name

List all available principles

Search principles by keyword

Estimated cost

Alternative options

Audit service value (cost/benefit)

Process a procurement order (GSA)

Fund a research project (NSF grant)

Confidence score

Whether chain is complete

Verdict (Permitted/Flagged)

Persistence level

Recommendation if mismatch

Audit treasury status

Convert signal asymmetry into resources (information arbitrage)

Run all standard folds (sum, count, min, max, mean, variance) in one pass.

Detect outliers using the IQR method.

Compute a specific percentile from values.

Rank items by value, optionally returning only top N.

Parse a JSON tree and perform recursive fold.

No cargo invocations — purely a DAG computation.

once all prior phases are complete.

referenced against the checkpoint file to produce a pending list.

Analyze a graph structure.

Compute betweenness centrality for all nodes

Find connected components (treating edges as undirected)

Construct a graph from various data sources.

Supports 2D and 3D layout, normalizes positions to [-1, 1].

Find shortest path between two nodes (BFS, unweighted)

Compute Betti numbers at a specific filtration value

Compute persistent homology from a distance matrix

Build a Vietoris-Rips complex and return its structure

Compose two confidence values multiplicatively (P(A∧B) = P(A) × P(B)).

Get the full evidence chain with all steps and current confidence.

Start a new evidence chain for a claim.

Add a step to an existing evidence chain (strengthen or weaken).

Gate a value on minimum confidence — returns Ok or rejects with explanation.

Run a grounded skill assessment (Bronze→Diamond compliance).

Wrap a value with confidence and get its band classification.

Append rows to the end of a table.

Read multiple cell ranges in one call.

List all sheet tabs in a Google Spreadsheet.

Get spreadsheet metadata.

Read a cell range from a Google Spreadsheet.

Search for a substring across all cells in a range.

Write values to a cell range.

Compare GSK plc adverse event reporting vs a competitor using PRR from FAERS

Get recent safety labeling changes for GSK plc products

Get GSK plc clinical trial pipeline — active and recruiting trials by phase

Get GSK plc approved product portfolio — brand names, generics, routes, pharmacologic classes

Get GSK plc product recalls and enforcement actions from FDA

Get GSK plc aggregate safety profile from FAERS — top adverse reactions, outcomes, products with most reports

Search GSK plc products by keyword — drug name, condition, or therapeutic area

List all registered actuators

Guardian Adversarial Input

Get autonomy-aware ceiling limits for an originator type

Evaluate PV risk context and get recommended responses

Get Guardian event history

Run one iteration of the homeostasis control loop

Inject a test signal into the Guardian system

Classify an entity by its {G, V, R} capabilities

Guardian Reset

List all registered sensors

Compute a point in 3D safety space

Check PHAROS status: existing reports, timer state.

Subscribe to Guardian events (polling snapshot)

Get the conservation law axiom connection for a specific harm type.

Return the complete catalog of all 8 harm types (A-H) with definitions, conservation laws violated, manifestation levels, and examples.

Classify a harm event by three binary attributes: multiplicity (single/multiple), temporal profile (acute/chronic), and response determinism (deterministic/stochastic).

List common harm type combinations that co-occur in clinical practice.

Get the hierarchy manifestation levels for a harm type.

Verify that the 8-type taxonomy is exhaustive — that all 2³=8 combinations of the three binary characteristics are covered.

Measure public health impact of signals

Validate signal efficacy against ground truth (FDA-style validation)

List all available heligrams with their metadata: name, version, twist rate, base pair count, and test count.

Run a heligram by name with input variables.

Run all self-tests for a heligram.

Run self-tests for all heligrams.

Advance one turn on the helix.

Validate ∃ = ∂(×(ς, ∅)) for a system.

Encode a concept through all 5 helix turns.

Compute position on the knowledge helix.

Test whether an action satisfies the mutualism constraint: does it produce ∃ for self WITHOUT reducing ∃ for others?

Compare Jiangsu Hengrui adverse event reporting vs a competitor using PRR from FAERS

Get recent safety labeling changes for Jiangsu Hengrui products

Get Jiangsu Hengrui clinical trial pipeline — active and recruiting trials by phase

Get Jiangsu Hengrui approved product portfolio — brand names, generics, routes, pharmacologic classes

Get Jiangsu Hengrui product recalls and enforcement actions from FDA

Get Jiangsu Hengrui aggregate safety profile from FAERS — top adverse reactions, outcomes, products with most reports

Search Jiangsu Hengrui products by keyword — drug name, condition, or therapeutic area

Classify a tool into Digital Highway tiers I-IV.

Compute destructive factor score for infrastructure stress.

Sort tools into grade-separated batches by highway class.

Merge N parallel tool results through grounded confidence composition.

Check if a tool is being used in its legitimate transportation field.

Plan parallel lanes for a batch of tool calls with grade separation.

Score a tool against the 7 Ideal Tool Qualities.

Run a traffic census on tool usage — reads brain.db telemetry.

Get a specific hormone level

Hormone Modifiers

Hormone Status

Apply a stimulus to the endocrine state

Get Singapore drug registration information

Get HSA safety alerts and Dear Healthcare Professional letters

Get product recall information

Search Singapore ADR database

Get ICH E2B(R3) ICSR data element categories — administrative info, patient data, drug info, reaction/event, narrative structure

Get ICH guideline summary and current step by code

Get MedDRA-related ICH guidelines and terminology references

Get all pharmacovigilance-related guidelines (E2x series)

Get ICH Quality (Q-series) guidelines — stability testing, analytical validation, impurities, QbD, lifecycle management

Get ICH Safety (S-series) guidelines — nonclinical safety pharmacology, carcinogenicity, genotoxicity, reproductive toxicology

Search ICH guidelines by topic, code, or keyword

Get a specific antibody by ID.

List all antibodies with optional filtering.

Propose a new antibody from an observed error/fix pair.

Returns threats found, their severity, and suggested responses.

Useful for learning from build failures.

Immunity Status

Compare Incyte Corporation adverse event reporting vs a competitor using PRR from FAERS

Get recent safety labeling changes for Incyte Corporation products

Get Incyte Corporation clinical trial pipeline — active and recruiting trials by phase

Get Incyte Corporation approved product portfolio — brand names, generics, routes, pharmacologic classes

Get Incyte Corporation product recalls and enforcement actions from FDA

Get Incyte Corporation aggregate safety profile from FAERS — top adverse reactions, outcomes, products with most reports

Search Incyte Corporation products by keyword — drug name, condition, or therapeutic area

Tier: T2-C (N + μ + κ — quantity reduction via mapping and comparison)

Tier: T2-C (N + μ + κ — automatic quantity reduction via clustering)

Tier: T2-P (∂ + ς — boundary configuration + state persistence)

Tier: T2-C (μ + κ + ς — mapping + comparison + state)

Tier: T3 (orchestrates all 6 composites via the Insight trait)

Tier: T2-C (∅ + ∃ + σ — void/existence detection in sequence)

Tier: T2-C (σ + κ + μ — sequence co-occurrence via comparison and mapping)

Tier: T2-C (κ + μ + σ — comparison-filtered query)

Tier: T1 (∅ — Void / clearing state)

Tier: T2-C (ς + N — state query + quantity)

Tier: T3 (full pipeline through unified engine)

Tier: T2-P (λ + ∃ — location + existence)

Tier: T1 (∅ — Void / clearing state)

Tier: T2-C (ς + N + Σ — state query + quantity + aggregation)

Compare Ipsen Biopharmaceuticals adverse event reporting vs a competitor using PRR from FAERS

Get recent safety labeling changes for Ipsen Biopharmaceuticals products

Get Ipsen Biopharmaceuticals clinical trial pipeline — active and recruiting trials by phase

Get Ipsen Biopharmaceuticals approved product portfolio — brand names, generics, routes, pharmacologic classes

Get Ipsen Biopharmaceuticals product recalls and enforcement actions from FDA

Get Ipsen Biopharmaceuticals aggregate safety profile from FAERS — top adverse reactions, outcomes, products with most reports

Search Ipsen Biopharmaceuticals products by keyword — drug name, condition, or therapeutic area

Compare Jazz Pharmaceuticals adverse event reporting vs a competitor using PRR from FAERS

Get recent safety labeling changes for Jazz Pharmaceuticals products

Get Jazz Pharmaceuticals clinical trial pipeline — active and recruiting trials by phase

Get Jazz Pharmaceuticals approved product portfolio — brand names, generics, routes, pharmacologic classes

Get Jazz Pharmaceuticals product recalls and enforcement actions from FDA

Get Jazz Pharmaceuticals aggregate safety profile from FAERS — top adverse reactions, outcomes, products with most reports

Search Jazz Pharmaceuticals products by keyword — drug name, condition, or therapeutic area

Jeopardy Board Control Value

List all Jeopardy categories with their compound multipliers.

List clue dollar values for a given round.

Compute compound velocity from game history.

Compute optimal Daily Double wager.

Jeopardy Optimal Final Wager

Score available board positions by strategic value (Holzhauer strategy).

Determine whether to buzz in on a specific clue.

Compare Johnson & Johnson adverse event reporting vs a competitor using PRR from FAERS

Get recent safety labeling changes for Johnson & Johnson products

Get Johnson & Johnson clinical trial pipeline — active and recruiting trials by phase

Get Johnson & Johnson approved product portfolio — brand names, generics, routes, pharmacologic classes

Get Johnson & Johnson product recalls and enforcement actions from FDA

Get Johnson & Johnson aggregate safety profile from FAERS — top adverse reactions, outcomes, products with most reports

Search Johnson & Johnson products by keyword — drug name, condition, or therapeutic area

List running Jupyter kernels.

List available kernel specifications.

Create a notebook with cells in one call via Jupyter REST API.

Execute all cells in a notebook using `jupyter nbconvert --execute --inplace`.

Reports which stages passed and the overall verdict.

Check PHAROS status: existing reports, timer state.

List the TTS model names accepted by the Kokoro upstream (kokoro, tts-1, tts-1-hd).

List all 67 voice identifiers available on the Kokoro upstream.

Synthesize speech from text using the Kokoro neural TTS model.

probability scores.

Get a specific hormone level

Search documents by query string

Get knowledge engine statistics.

lightest/heaviest, average weight, std dev, class distribution.

weight delta, shared/unique primitives, Jaccard similarity.

Pipeline: Decompose → Weigh → Classify → Analyze → Report

Enthalpy (ΔH) measures weight efficiency: negative = exothermic (more compact).

Learn Assimilate

Learn Extract

Learn Landscape

Learn Normalize

Learn Pipeline

Learn Recall

Learning Daemon Beliefs

Learning Daemon Corrections

Learning Daemon Status

Learning Daemon Trends

Learning Daemon Velocity

height values for terrain mesh rendering.

Add a new lesson with automatic primitive extraction.

Filter lessons by context.

Filter lessons by tag.

Get a lesson by ID.

Search lessons by query string.

Compare Eli Lilly and Company adverse event reporting vs a competitor using PRR from FAERS

Get recent safety labeling changes for Eli Lilly and Company products

Get Eli Lilly and Company clinical trial pipeline — active and recruiting trials by phase

Get Eli Lilly and Company approved product portfolio — brand names, generics, routes, pharmacologic classes

Get Eli Lilly and Company product recalls and enforcement actions from FDA

Get Eli Lilly and Company aggregate safety profile from FAERS — top adverse reactions, outcomes, products with most reports

Search Eli Lilly and Company products by keyword — drug name, condition, or therapeutic area

Tier: T3 (nexcore-caesura × MCP integration)

Tier: T3 (nexcore-caesura × MCP integration)

Tier: T3 (nexcore-caesura × MCP integration)

Vocab List

Look up skills associated with a vocabulary shorthand

Compare Lupin Limited adverse event reporting vs a competitor using PRR from FAERS

Get recent safety labeling changes for Lupin Limited products

Get Lupin Limited clinical trial pipeline — active and recruiting trials by phase

Get Lupin Limited approved product portfolio — brand names, generics, routes, pharmacologic classes

Get Lupin Limited product recalls and enforcement actions from FDA

Get Lupin Limited aggregate safety profile from FAERS — top adverse reactions, outcomes, products with most reports

Search Lupin Limited products by keyword — drug name, condition, or therapeutic area

How big is the this MCP surface?

START HERE.

Get started.

Run a live 3-step demo with real data.

Show a multi-tool chain that demonstrates compound value.

Analyze a Markov chain.

Estimate a Markov chain from observed state sequences.

Compare two crates side-by-side: health scores, LOC ratio, test density diff.

Measure a single crate's health: LOC, test count, entropy, and composite score.

Detect statistically significant metric drift using Welch's t-test on history.

Compute Shannon entropy, max entropy, and redundancy from category counts.

Measure Graph

Compute statistical summary: mean, variance, 95% CI, and linear regression.

Measure Workspace

Get complete MedDRA hierarchy structure — 5 levels (LLT→PT→HLT→HLGT→SOC) with counts, relationships, and multi-axiality

Get MedDRA multi-axiality guidance — how PTs map to multiple SOCs with primary/secondary designation and impact on signal detection

Get Standardised MedDRA Query terms for a safety topic

List all Preferred Terms under a System Organ Class

Get the full MedDRA hierarchy path for a preferred term

Get MedDRA version information, biannual update cycle, and MSSO maintenance organization details

Search MedDRA terms across all hierarchy levels (SOC, HLGT, HLT, PT, LLT)

Extract the breadcrumb path showing the drug's categorization (e.g., Home → Drugs, Herbs and Supplements → Aspirin).

Extract dosing and administration instructions (how should this medicine be used).

Extract the drug name (h1 title) from a MedlinePlus drug monograph page.

Extract why the medication is prescribed (indications, on-label and off-label uses).

Extract special precautions and contraindications for the drug.

List all section headings present on a drug monograph (Why prescribed, Dosing, Precautions, Side effects, etc.).

Get approved New Zealand data sheet for a medicine

Get Prescriber Update bulletin safety articles

Get Medsafe safety communications and alerts

Search CARM adverse reaction reports (Centre for Adverse Reactions Monitoring)

Compare Menarini Group adverse event reporting vs a competitor using PRR from FAERS

Get recent safety labeling changes for Menarini Group products

Get Menarini Group clinical trial pipeline — active and recruiting trials by phase

Get Menarini Group approved product portfolio — brand names, generics, routes, pharmacologic classes

Get Menarini Group product recalls and enforcement actions from FDA

Get Menarini Group aggregate safety profile from FAERS — top adverse reactions, outcomes, products with most reports

Search Menarini Group products by keyword — drug name, condition, or therapeutic area

Compare Merck & Co.

Get recent safety labeling changes for Merck & Co.

Get Merck & Co.

Get Merck & Co.

Get Merck & Co.

Get Merck & Co.

Search Merck & Co.

Check consistency of terms across multiple corpora

Cross-reference a term across MESH, MedDRA, SNOMED, ICH

Enrich a PubMed article with MESH descriptors

Lookup a MESH descriptor by UI or name

Mesh Network Grounding

Tier: T2-C (Cross-domain composite tool)

Tier: T2-C (Cross-domain composite tool)

Tier: T3 (Domain-specific MCP tool)

Search documents by query string

Navigate MESH tree hierarchy

Get Korea pharmacovigilance and ADR reports

Get Korea drug recall and withdrawal actions

Get Korea regulatory classification and approval status

Get Korea drug safety alerts and communications

Search Korea drug registration database

List all available microgram chains with their step sequences.

List all available micrograms with their descriptions and test counts.

Antibody: detects quantity conservation violations (stem-phys Preserve trait).

Antibody: detects cortisol saturation (stem-bio burnout threshold).

Antibody: detects force applied to zero mass (stem-phys F=ma — infinite acceleration).

Antibody: detects hormone level outside [0,1] range (stem-bio invariant).

Antibody: detects enzyme/receptor saturation using Michaelis-Menten model.

Pharmacokinetics: absorption-rate assessment

Pharmacokinetics: accumulation-index assessment

Pharmacokinetics: acetylation assessment

Route flywheel composite health actions to specific remediation strategies.

Classify actuator/sensor ratio: BALANCED (2-5:1), SENSOR_HEAVY (>5:1), ACTUATOR_HEAVY (<2:1)

Adapter: convert evidence_strength from pubmed/literature configmigrams to signal pipeline inputs

Adapter: transforms openFDA FAERS drug_event counts into the input shape needed by PRR/disproportionality computation.

Adapter: convert interaction severity from RxNav/DrugBank configmigrams to signal pipeline inputs

Adapter: transforms DailyMed labeling data (adverse_reactions section) into the input shape needed by expectedness-check microgram.

Adapter: convert risk_tier from DailyMed/recall configmigrams to signal pipeline inputs

Adapter: convert safety_concern from trial SAE triage to seriousness boolean for causality pipeline

Adapter: convert configmigram signal_strength to signal pipeline inputs (signal_detected + synthetic prr)

Determine if drug requires additional monitoring (black triangle symbol) based on regulatory status, market tenure, and conditions.

Clinical safety: administration-route

Domain 2: Classify adverse drug reaction by type (A-F) — mechanism, predictability, dose-dependence, clinical approach.

Domain 3: Grade ADR severity and determine response urgency — maps to CTCAE-style grading with clinical action.

ADR CTCAE grading → escalation routing.

Clinical safety: adr-severity-gate

Determines whether the agent station can handle a query or needs external help

Routes aggregate data assessment to PSUR section assignment and prioritization

PDC: EPA 10 AI Gateway typestate — route phase by current level to next phase and CPA 8 unlock

PDC: Validate EPA10 AI Gateway prerequisites by phase — checks domain levels, exam scores, and project evidence

PVOS alert configuration: validates alert config completeness - requires threshold, notification channel, and valid severity level

Route signal type + value to threshold action using Evans criteria and standard PV thresholds

Algovigilance: triage bias signals by disparity ratio, affected population size, and protected attribute category

Algorithm 8 (CONVERGE): Fixpoint iteration for signal stability.

Algovigilance: classify AI model drift severity from distribution shift metrics (PSI, KS p-value) and observation window

Algorithm 7 (ENERGY): Measures N(→(Δς)) — capacity for change.

Algorithm 10 (LOCATE): Boundary contraction search.

Algorithm 11 (SEAL): Irreversible commitment gate.

Algorithm 12 (SELECT): Differential survival.

Algovigilance: route a classified algo signal to the correct response action based on signal type and severity

Bridge microgram: maps signal-deep-validation outputs to pv-12-algorithm-assessment inputs.

Algorithm 9 (VOID): Detect what's missing.

Ecosystem health gate: detects unresolved field name mismatches that reduce chain connectivity

PDC: Domain 1 (Foundations of PV) behavioral anchors by level — 7 anchors per level, 49 total

PDC: Domain 2 (Clinical ADRs) behavioral anchors by level — 7 anchors per level, 49 total

PDC: Validate behavioral anchor verb against expected competency level (Bloom's taxonomy mapping)

Station operations: annotation-coverage

Classify a confirmed harm signal into its anti-vector strategy.

Signal-to-prescription pipeline: PRR signal detection → anti-vector classification.

Score antibody fleet coverage: LOW (<10), MODERATE (10-20), HIGH (21-30), SATURATED (>30)

Flywheel operational: antibody-gap-finder

Development gate: api-breaking-change

APPE Ch7: Route participant to appropriate PV activity by week and level.

APPE Ch7.2 Domain 2: ADR classification practice — maps reaction characteristics to DoTS/WHO type (A/B/C) with confidence and teaching points.

APPE Ch7.5: AI ethics decision gate — evaluates ethical reasoning about AI in pharmacovigilance across 5 core principles

APPE Ch7.2: Formative and summative assessment gates.

APPE Ch7.4 Domain 14 L2: Adapts PV communication style, language level, and format for clinicians, regulators, patients, executives, and media.

APPE Ch7.6: APPE-to-Fellowship bridge assessment.

APPE Ch7.3: Select appropriate foundational EPA and PV tool chain by week and domain levels.

APPE Ch7.4: Score Foundation-Communication Integration Module (D1+D14) quality.

APPE Ch7.2/7.6: Portfolio completeness tracker — assesses evidence collection progress across domains.

APPE Ch7.6: Behavioral anchor rubric scorer — rates a single observation on the 4-point scale (1=Beginning to 4=Exemplary) across three dimensions

APPE Ch7.2 Domain 2 L1: Temporal pattern recognition for adverse event causality — classifies onset pattern and strengthens/weakens signal via dechallenge/rechallenge evidence.

APPE Ch7: Gate week progression based on behavioral anchor scores across Domains 1-3 and 14.

Pharmacokinetics: area-under-curve assessment

PDC: Route to assessment method based on competency type and level

Development gate: async-complexity-gate

PVOS audit subsystem: routes audit log queries to the correct operation scope (ingest/detect/triage/report/all)

Loop 3 FlywheelVitals: Friction measurement.

Autopilot decision gate for pharmaceutical company monitoring sweep.

Pharmacokinetics: bbb-permeability assessment

Run the benefit-risk assessment chain: weighs therapeutic benefit against safety risk using PRR, Naranjo, NNH, and therapeutic index.

Simple benefit-risk assessment gate determining product balance and regulatory action recommendation.

Academy L2: Given QBRI score and component weights, classify benefit-risk balance and provide regulatory learning feedback.

Benefit-risk decision gate for initial pharmacovigilance assessment: routes to monitoring, management, or mitigation based on benefit/risk scores and unmet need

Compute benefit-risk classification from numeric scores.

Domain 9: Identify bias type and route to appropriate control strategy — selection, information, confounding.

Pharmacokinetics: biliary-excretion assessment

Development gate: binary-size-gate

Clinical safety: bioavailability-gate

Pharmacokinetics: bioavailability-oral assessment

Pharmacokinetics: bioequivalence-gate assessment

Clinical safety: black-box-detector

Clinical safety: blood-brain-barrier

PDC: Map observed behavioral verb category to Bloom taxonomy tier (1-7) for anchor validation

Bone safety classifier: maps skeletal adverse reactions to severity grades for osteonecrosis, fractures, and bone mineral density loss

NexCore boundary threading classifier: routes data stream intersections through boundary hierarchy to determine verification level and analytical precision

Domain 10: Route to benefit-risk assessment framework by complexity, stakeholder needs, and quantitative requirement.

Bradford Hill evidence assessment: signal comparison → dose-response classification → Naranjo causality.

Full 5-criterion Bradford Hill causality assessment: temporal association → signal comparison → dose-response → rechallenge → Naranjo.

Development gate: branch-staleness

Pharmacokinetics: breast-milk-excretion assessment

Closed-loop build management chain: memory-gate → job-scaler → build → cache-prune.

Adaptive build parallelism scaler.

Pre-build memory gate: checks available RAM + free swap against crate build requirements.

Translates build resource metrics (headroom, cache state) into system health status and severity.

Development gate: build-time-gate

Business Value metric BV-01 metric CQ-01

Business Value metric BV-02 metric CQ-01

Business Value metric BV-03 metric CQ-01

Business Value metric BV-04 metric CQ-01

Competency Architecture CA-01 metric PDC-01

Competency Architecture CA-02 metric PDC-01

Competency Architecture CA-03 metric PDC-01

Competency Architecture CA-04 metric PDC-01

Competency Architecture CA-05 metric PDC-01

Competency Architecture CA-06 metric PDC-01

Competency Architecture CA-07 metric PDC-01

Competency Architecture CA-08 metric PDC-01

Competency Architecture CA-09 metric PDC-01

Competency Architecture CA-10 metric PDC-01

Competency Architecture CA-11 metric PDC-01

Competency Architecture CA-12 metric PDC-01

Competency Architecture CA-13 metric PDC-01

Competency Architecture CA-14 metric PDC-01

Competency Architecture CA-15 metric PDC-01

Station operations: cache-hit-ratio

Station operations: canary-gate

Scores a work candidate on 5 dimensions (Atomicity, Permanence, Unblock, Vision, Ground-clearing) and blends with raw urgency for final composite.

Clinical safety: carcinogenicity-tier

Cardiac safety classifier: maps cardiac adverse reactions to severity grades using ICH E14 QT prolongation thresholds and known cardiotoxicity signals

Run the complete case assessment chain: case validity → seriousness classification → causality evidence → regulatory action.

PDC competency assessment: case-coding proficiency classifier

Translates data completeness assessment and CIOMS frequency classification into case quality tier.

PVOS case ingestion: validates case data completeness before ingestion - requires drug, event, and reporter to proceed

PDC competency assessment: case-intake proficiency classifier

PVOS lifecycle router: advances cases through new->triage->assessment->reporting->closed based on state and completion conditions

PDC competency assessment: case-narrative proficiency classifier

PDC competency assessment: case-quality proficiency classifier

Routes ICSR cases through quality assessment into triage.

Evaluates case report completeness against ICSR criteria

Classify case seriousness per ICH E2A criteria.

Transforms case data into standardized signal feed record for PRR computation

PDC competency assessment: case-triage proficiency classifier

ICSR validity checker: enforces 4 minimum criteria per ICH E2B(R3) — reporter, patient, suspect drug, adverse event

Pipeline completo de evaluación de caso clínico en español.

Academy L2: Given a Naranjo score and WHO-UMC categorical inputs, validate dual causality assessment and provide learning feedback on agreement/disagreement between the two methods.

Aggregates temporal association, dechallenge/rechallenge, and Naranjo score into unified causality verdict.

Domain 2: Route to appropriate causality assessment method based on case complexity, data availability, and context.

Bridge: routes causality assessment results to regulatory action with ICH E2B deadlines.

Run an ad-hoc microgram chain by expression.

CPA Integration CI-01 metric PDC-01

CPA Integration CI-02 metric PDC-01

CPA Integration CI-03 metric PDC-01

CPA Integration CI-04 metric PDC-01

CPA Integration CI-05 metric PDC-01

CPA Integration CI-06 metric PDC-01

CPA Integration CI-07 metric PDC-01

CPA Integration CI-08 metric PDC-01

CPA Integration CI-09 metric PDC-01

Regulatory decision: cioms-form-selector

CIOMS frequency classification for adverse reactions per EU SmPC Section 4.8 labeling convention

Regulatory decision: cioms-working-group-router

Evaluates clinical trial maturity and safety data availability.

Development gate: clippy-warning-gate

Positive or gate

Domain 14: Route to communication channel and approach by stakeholder type — regulatory, HCP, patient, internal, partner.

Development gate: commit-message-quality

Loop 1 FlywheelVitals: Community value network health.

Compatibility Predictor: predicts whether two micrograms will be cross-compatible based on empirical matrix findings.

PDC competency assessment: compliance-audit proficiency classifier

PDC competency assessment: compliance-documentation proficiency classifier

Maps case processing outputs to ICH control evidence.

PDC competency assessment: compliance-gap proficiency classifier

PDC competency assessment: compliance-remediation proficiency classifier

PDC competency assessment: compliance-reporting proficiency classifier

Case lifecycle FSM for compliance tracking: RECEIVED -> VALIDATED -> ASSESSED -> REPORTED -> CLOSED.

Flywheel operational: composite-health-aggregator

Assessment confidence level → reporting urgency classification.

Gate on confidence level: HIGH (>=0.8), MEDIUM (>=0.5), LOW (<0.5)

Classify ADR risk level from DailyMed label adverse reactions section.

Station operations: config-diff-impact

Gate drug-drug interaction data from DrugBank get-interactions.

Classify EMA PRAC safety signal output into action priority.

Triage EudraVigilance ICSR volume and ROR signal data

Classify FDA recall severity from accessdata search-recalls output.

Classify FDA safety communication urgency from search output

Station operations: config-freshness-gate

Gate ICH guideline applicability by code series and step

Triage OpenVigil disproportionality output.

Score evidence strength from PubMed search-signal-literature results.

Classify drug interaction severity from RxNav get-interactions output.

Triage clinical trial safety data from compare-trial-arms or get-serious-adverse-events output.

Classify geographic spread of WHO VigiAccess adverse reaction reports.

Route WHO-UMC causality assessment categories to PV actions.

Station operations: connection-pool-health

Validates primitive compositions against the conservation law ∃ = ∂(×(ς, ∅)).

Clinical safety: contraindication-flag

PDC: Full coordinator pipeline — classify task scope, determine HITL level, identify domain, route to CPA agent

Classify correction recency: FRESH (<7d), AGING (7-30d), STALE (>30d)

Flywheel operational: correction-impact-scorer

Station operations: cors-compliance

Data coverage tier classifier: maps a 0-100 coverage percentage to quality tiers for PV data source assessment

CPA capability matrix — given a CPA and level, returns what that CPA can produce at that competency level.

PDC: Return full CPA specification by ID — primary/supporting domains, EPA mappings, AI components, integration modules, agent routing

PDC: Route CPA (1-8) to practice function with capstone detection

Compliance & Quality metric CQ-01

Compliance & Quality metric CQ-02

Compliance & Quality metric CQ-03

Compliance & Quality metric CQ-04

Compliance & Quality metric CQ-05

Compliance & Quality metric CQ-06

Crate architectural fitness classifier.

Development gate: crate-size-gate

Domain 14: Crisis communication routing by severity and timeline — immediate response through recovery.

Pharmacokinetics: crossover-design assessment

Brain backup freshness for trust flywheel: GREEN (<12h), YELLOW (<24h), RED (>24h or missing)

Aggregate 4 crypto micrograms into single GREEN/YELLOW/RED.

Crypto infrastructure health for flywheel homeostasis: GREEN (all ok), YELLOW (degraded), RED (keys missing)

Provenance manifest coverage for insight flywheel: GREEN (all signed), YELLOW (partial), GREY (none yet)

Microgram signature coverage for immunity flywheel: GREEN (100%), YELLOW (partial), RED (none)

Crystalbook 4-Primitive Conservation Check: assess whether a system conserves Existence (∃), Boundary (∂), State (ς), and Nothing (∅).

Crystalbook 8-Law Risk Matrix: assess virtue scores (0-10) for each of the 8 Laws of System Homeostasis.

Crystalbook Full Diagnostic: combines 4-primitive conservation check + law triage into a single diagnostic.

Domain 13: Route to cultural adaptation strategy by dimension — communication, decision-making, authority, safety reporting.

CUSUM (cumulative sum) control chart for sequential signal surveillance.

Classifies Controller::tick verdicts into escalation tiers.

Pharmacokinetics: cyp1a2-substrate assessment

Pharmacokinetics: cyp2c19-substrate assessment

Pharmacokinetics: cyp2c9-substrate assessment

Pharmacokinetics: cyp2d6-substrate assessment

Pharmacokinetics: cyp3a4-substrate assessment

Clinical safety: cytochrome-p450-interaction

Cytokine release syndrome classifier: grades CRS severity per ASTCT 2019 consensus grading

PVOS dashboard: classifies metric health as HEALTHY/WARNING/CRITICAL using standard PV operational thresholds (warn>=70, critical>=90)

Assess data completeness: COMPLETE (>=95%), PARTIAL (>=70%), INSUFFICIENT (<70%)

Domain 7: Assess data quality dimension and route to appropriate validation action — completeness, accuracy, consistency, timeliness, integrity.

Assesses whether sufficient data exists to proceed to the next analysis step in a PV investigation

Classify a PV DD domain risk level from its raw score (0-100).

PV DD GO/NO-GO decision gate.

Classify DD risk multiplier severity from count and type of active multipliers.

Bridge: regulatory deadline + confidence actionability → alert routing.

Dashboard deadline urgency: maps days remaining to traffic level for PV operations center display

Assess dechallenge/rechallenge evidence for drug-event causality.

Classify flywheel score delta between sessions: SURGE (>+10), GROWTH (+3..+10), STABLE (-2..+2), DECLINE (-10..-3), CRASH (<-10)

NexCore denominator confidence scorer: classifies denominator reliability based on data source characteristics, capture rate, and boundary resolution

Development gate: dependency-freshness

Bridge: test verdict deploy flag + quality score ship flag → release approval.

Development gate: deploy-safety-gate

Station operations: deployment-risk-scorer

Dermatologic safety classifier: maps skin adverse reactions to severity grades with SJS/TEN/DRESS as critical signals

Digital Innovation metric DI-01 metric CQ-01

Digital Innovation metric DI-02 metric CQ-01

Digital Innovation metric DI-03 metric CQ-01

Digital Innovation metric DI-04 metric CQ-01

Flywheel operational: dimension-bottleneck-finder

Walt Disney Creative Strategy — evaluate a concept through Dreamer (vision), Realist (execution), and Critic (failure modes) rooms, producing a readiness verdict

Consensus signal classifier across all 4 disproportionality measures (PRR, ROR, IC, EBGM).

Pharmacokinetics: distribution-volume assessment

Station operations: dns-resolution-check

Development gate: doc-density-gate

PDC: Classify competency domain ID (1-15) into thematic group and layer

PDC: Return full domain specification by ID — name, cluster, definition, knowledge count, skill count, AI integration points

Clinical safety: dose-adjustment-hepatic

Clinical safety: dose-adjustment-renal

Pharmacokinetics: dose-escalation assessment

Pharmacokinetics: dose-proportionality assessment

Dose-response relationship classifier: takes low_dose_rate, mid_dose_rate, and high_dose_rate adverse event frequencies and classifies the relationship pattern.

Safety dossier completeness scorer: evaluates FAERS, guideline, and competitor data availability to classify dossier as comprehensive/adequate/minimal/empty with a 0-100 score

PVOS drift alerting: classifies signal drift severity based on PRR change magnitude and time window

Signal drift direction classifier: determines whether a signal metric is rising, falling, or stable based on percentage change

Pharmacokinetics: drug-accumulation assessment

Clinical safety: drug-class-router

Differential drug safety classification: compares two drug profiles by pre-computed signal ratio and PRR ratio to determine which has worse safety profile

Classify whether one drug adverse event rate is meaningfully higher than another using a 1.2x threshold on pre-computed ratio

Pharmacokinetics: drug-food-interaction assessment

Pharmacokinetics: drug-herb-interaction assessment

Determines if multiple data sources are referring to the same drug entity

Clinical safety: drug-interaction-checker

Resolves drug name type and routes to appropriate nomenclature source (RxNorm, WHO-DD, DailyMed)

Safety profile classifier for albuterol.

Safety profile classifier for alendronate.

Safety profile classifier for allopurinol.

Safety profile classifier for alprazolam.

Safety profile classifier for amitriptyline.

Safety profile classifier for amphetamine.

Safety profile classifier for anastrozole.

Safety profile classifier for apixaban.

Safety profile classifier for aripiprazole.

Safety profile classifier for aspirin.

Safety profile classifier for atenolol.

Safety profile classifier for atomoxetine.

Safety profile classifier for baclofen.

Safety profile classifier for benazepril.

Safety profile classifier for bupropion.

Safety profile classifier for buspirone.

Safety profile classifier for carbidopa-levodopa.

Safety profile classifier for carvedilol.

Safety profile classifier for cefdinir.

Safety profile classifier for celecoxib.

Safety profile classifier for cephalexin.

Safety profile classifier for cetirizine.

Safety profile classifier for chlorthalidone.

Safety profile classifier for citalopram.

Safety profile classifier for clindamycin.

Safety profile classifier for clonazepam.

Safety profile classifier for clonidine.

Safety profile classifier for colchicine.

Safety profile classifier for cyclobenzaprine.

Safety profile classifier for dexmethylphenidate.

Safety profile classifier for diazepam.

Safety profile classifier for diclofenac.

Safety profile classifier for digoxin.

Safety profile classifier for diltiazem.

Safety profile classifier for divalproex.

Safety profile classifier for donepezil.

Safety profile classifier for doxazosin.

Safety profile classifier for doxycycline.

Safety profile classifier for duloxetine.

Safety profile classifier for enalapril.

Safety profile classifier for escitalopram.

Safety profile classifier for esomeprazole.

Safety profile classifier for estradiol.

Safety profile classifier for ezetimibe.

Safety profile classifier for famotidine.

Safety profile classifier for fenofibrate.

Safety profile classifier for fexofenadine.

Safety profile classifier for finasteride.

Safety profile classifier for fluconazole.

Safety profile classifier for fluticasone.

Safety profile classifier for furosemide.

Safety profile classifier for gemfibrozil.

Safety profile classifier for glimepiride.

Safety profile classifier for glipizide.

Safety profile classifier for glyburide.

Safety profile classifier for guanfacine.

Safety profile classifier for hydralazine.

Safety profile classifier for hydrocodone.

Safety profile classifier for hydroxychloroquine.

Safety profile classifier for hydroxyzine.

Safety profile classifier for insulin.

Safety profile classifier for irbesartan.

Safety profile classifier for isosorbide-mononitrate.

Safety profile classifier for lamotrigine.

Safety profile classifier for lansoprazole.

Safety profile classifier for latanoprost.

Safety profile classifier for levetiracetam.

Safety profile classifier for levofloxacin.

Safety profile classifier for levothyroxine.

Safety profile classifier for lidocaine.

Safety profile classifier for linagliptin.

Safety profile classifier for loperamide.

Safety profile classifier for loratadine.

Safety profile classifier for lorazepam.

Safety profile classifier for lovastatin.

Safety profile classifier for meloxicam.

Safety profile classifier for memantine.

Safety profile classifier for methylphenidate.

Safety profile classifier for methylprednisolone.

Safety profile classifier for metoclopramide.

Safety profile classifier for metronidazole.

Safety profile classifier for mirtazapine.

Safety profile classifier for montelukast.

Safety profile classifier for morphine.

Safety profile classifier for naproxen.

Safety profile classifier for nifedipine.

Safety profile classifier for nitrofurantoin.

Safety profile classifier for nitroglycerin.

Safety profile classifier for nortriptyline.

Safety profile classifier for olanzapine.

Safety profile classifier for olmesartan.

Safety profile classifier for ondansetron.

Safety profile classifier for oseltamivir.

Safety profile classifier for oxcarbazepine.

Safety profile classifier for oxybutynin.

Safety profile classifier for oxycodone.

Safety profile classifier for pantoprazole.

Safety profile classifier for paroxetine.

Safety profile classifier for penicillin.

Safety profile classifier for phenazopyridine.

Safety profile classifier for phenytoin.

Safety profile classifier for pioglitazone.

Safety profile classifier for potassium-chloride.

Safety profile classifier for pravastatin.

Safety profile classifier for prednisolone.

Safety profile classifier for pregabalin.

Safety profile classifier for promethazine.

Safety profile classifier for propranolol.

Safety profile classifier for quetiapine.

Safety profile classifier for quinapril.

Safety profile classifier for rabeprazole.

Safety profile classifier for ramipril.

Safety profile classifier for ranitidine.

Safety profile classifier for risperidone.

Safety profile classifier for rivaroxaban.

Safety profile classifier for ropinirole.

Safety profile classifier for rosuvastatin.

Safety profile classifier for sildenafil.

Safety profile classifier for sitagliptin.

Safety profile classifier for spironolactone.

Safety profile classifier for sulfamethoxazole-trimethoprim.

Safety profile classifier for sumatriptan.

Safety profile classifier for tamsulosin.

Safety profile classifier for temazepam.

Safety profile classifier for tirzepatide.

Safety profile classifier for tizanidine.

Safety profile classifier for topiramate.

Safety profile classifier for trazodone.

Safety profile classifier for triamcinolone.

Safety profile classifier for valacyclovir.

Safety profile classifier for valsartan.

Safety profile classifier for venlafaxine.

Safety profile classifier for verapamil.

Safety profile classifier for zolpidem.

Classifies overall drug safety profile based on multiple signal dimensions: signal count, serious proportion, fatal count, REMS, and boxed warning status

Domain 5: DSMB recommendation routing — continue, modify, or terminate based on safety/efficacy balance and stopping rules.

Duplicate case detection: classifies case pairs as CONFIRMED/PROBABLE/POSSIBLE/UNLIKELY duplicate based on matching criteria and time window

ICH E2A Section 2: Classify whether an event is an Adverse Event (AE) or Adverse Drug Reaction (ADR) based on causal relationship and temporal association

ICH E2A Section IV: Case completeness scorer — assesses data quality for an expedited safety report across 5 data domains: patient, drug, event, outcome, reporter.

ICH E2A Section 3: Maps causality assessment terminology to standardized categories for regulatory reporting

ICH E2A Section II.D: Concomitant medication causality gate — determines whether a concomitant (non-suspect) drug may be contributing to the adverse event, affecting causality attribution and reporting requirements

ICH E2A Section IV.A: Data collection priority scorer — determines urgency and priority of follow-up data collection based on case characteristics.

ICH E2A Section II.B: Disability/incapacity sub-classification — distinguishes significant persistent disability (seriousness criterion) from temporary impairment (not a criterion)

ICH E2A Section II.C: Determines expectedness of an adverse reaction — listed (expected) vs unlisted (unexpected) in the Reference Safety Information (RSI/IB/SmPC)

ICH E2A Section 4.3: Determines if follow-up information is required for a safety report based on seriousness, outcome, and expectedness

ICH E2A Section II.B: Hospitalization sub-classification — initial (new), prolonged (extension of existing), or elective/planned (not a seriousness criterion).

ICH E2A investigator urgency gate: determines reporting urgency based on SAE awareness and severity

ICH E2A Section II.A.4: Medically important event gate — classifies events that may jeopardize patient or require intervention to prevent other seriousness outcomes.

ICH E2A / CIOMS-I minimum ICSR validity gate: all 4 elements (reporter, patient, drug, event) must be identifiable

ICH E2A Section IV.B: Classifies the outcome of an adverse event into 5 standardized ICH categories: recovered, recovering, not_recovered, fatal, unknown — with follow-up implications

ICH E2A orchestration router: routes an incoming case through the correct E2A assessment pipeline based on case type and available data.

ICH E2A Section III.A: Sponsor reporting obligation gate — determines whether a case must be reported as an expedited SUSAR, combining seriousness + unexpectedness + causality in a clinical trial context

ICH E2A Section III.B: Expedited reporting timeline router — 7-day for fatal/life-threatening unexpected, 15-day for all other serious unexpected, no expedited for serious expected

ICH E2A Section III.A: Clinical trial sponsor reporting gate — determines if sponsor must submit expedited safety report to regulatory authority based on study phase, case type, and applicable regulations

ICH E2A bridge: maps SUSAR classification output to specific reporting deadline.

ICH E2A blinded study unblinding gate: determines whether treatment unblinding is recommended for expedited reporting

Regulatory decision: e2b-field-validator

ICH E2C(R2) Section 7: Determines if the benefit-risk balance has changed since the last PBRER based on new safety signals, efficacy changes, and risk minimization effectiveness

ICH E2C(R2) Section 2: Determines PBRER reporting interval based on product lifecycle stage, approval duration, and risk management requirements

ICH E2C(R2) Section 5: Evaluates whether a signal warrants inclusion in PBRER based on source, strength, and validation status

ICH E2D Section 4.3: Determines whether a blinded post-approval study case requires unblinding for expedited reporting purposes

ICH E2D Section 3.2: Validates whether a consumer (non-HCP) report meets minimum criteria for processing

ICH E2D Section 4.2: Determines whether a post-approval serious unexpected ADR requires notification to ethics committees and investigators

ICH E2D Section 2.2: Determines expectedness of a post-approval adverse drug reaction against the reference safety information (SmPC or CCDS)

ICH E2D Section 5: MAH follow-up obligation for incomplete serious adverse drug reaction reports — determines if active follow-up is required and the deadline

ICH E2D Section 3.3: Determines if a literature article requires safety case extraction based on article type and content

ICH E2D Section 4: MAH post-approval reporting obligation classifier — determines which regulatory authorities require expedited ICSRs and which submission pathway applies

ICH E2D Section 3.1: Validates minimum four-element criteria for any post-approval ICSR — identifiable reporter, identifiable patient, suspect drug, adverse event.

ICH E2D Section 4.3: Classifies post-approval study safety report type and determines whether IND-equivalent expedited reporting applies or periodic reporting suffices

ICH E2D Section 1-4 workflow orchestrator: Routes a post-approval ICSR through source classification, minimum criteria, seriousness, and reporting pathway determination.

ICH E2D Section 4.1: Post-approval expedited reporting timeline for serious unexpected adverse drug reactions — 7-day for fatal/life-threatening, 15-day for other serious unexpected

ICH E2D Section 6 / ICH E2C(R2): Determines PSUR/PBRER submission interval and due date trigger based on product lifecycle and regulatory status

ICH E2D Section 3: Classifies the source type of a post-approval safety report and determines reportability

Bridge: E2A seriousness outputs (is_serious, is_fatal, is_life_threatening) to E2D post-marketing action.

ICH E2D Section 7: Determines the regulatory communication action required when a safety signal is identified post-approval — from routine PSUR inclusion to urgent Dear Healthcare Professional letter

ICH E2E Section 4: Determines the type of pharmacovigilance action needed for a safety concern based on risk category, seriousness, frequency, and plausibility

ICH E2E Section 3: Categorizes safety concerns into the three E2E risk categories — identified risk, potential risk, or missing information

ICH E2E Section 3.5: Flags whether special population safety data gaps exist for pediatric, geriatric, pregnant, renal-impaired, or hepatic-impaired populations

Empirical Bayes Geometric Mean (EBGM) signal detection gate.

Master health gate for the this ecosystem.

EIG Priority Ranker (ALG-2025-012): ranks which drug-event pair to investigate next.

Flywheel material elastic equilibrium classifier.

Regulatory decision: ema-epar-section

Endocrine disruption classifier: maps hormonal and endocrine adverse reactions to severity grades for thyroid, adrenal, and metabolic disorders

Station operations: endpoint-availability

Pharmacokinetics: enteric-coating-effect assessment

Efficiency metric EP-01 metric CQ-01

Efficiency metric EP-02 metric CQ-01

Efficiency metric EP-03 metric CQ-01

Efficiency metric EP-04 metric CQ-01

Efficiency metric EP-05 metric CQ-01

PDC: Classify EPA (1-20) into Core/Executive tier with AI gateway detection

PDC: Return full EPA specification by ID (1-20) — name, tier, primary/supporting domains with min levels, CPA mapping

PDC: Check if a professional's domain levels meet an EPA's minimum requirements (core EPAs 1-10)

EPA 1: Process ICSR — triage, collect, assess, code, narrate, submit.

EPA 10: AI tool validation — routes by validation stage, risk level, and regulatory requirement.

EPA 5: Detect and validate safety signals — routes by signal strength, evidence quality, and clinical significance.

EPA 7: Design risk minimization — routes by risk severity, population scope, and intervention type needed.

EPA 9: Quality and compliance — routes by finding type, severity, and CAPA requirements.

EPA Progression EPX-01 metric PDC-01

EPA Progression EPX-02 metric PDC-01

EPA Progression EPX-03 metric PDC-01

EPA Progression EPX-04 metric PDC-01

EPA Progression EPX-05 metric PDC-01

EPA Progression EPX-06 metric PDC-01

EPA Progression EPX-07 metric PDC-01

EPA Progression EPX-08 metric PDC-01

EPA Progression EPX-09 metric PDC-01

EPA Progression EPX-10 metric PDC-01

EPA Progression EPX-11 metric PDC-01

EPA Progression EPX-12 metric PDC-01

Domain 6: Classify medication error by type and stage in the medication use process — prescribing through monitoring.

Development gate: error-handling-ratio

Station operations: error-rate-gate

Domain 6: Grade medication error outcome severity — near miss through fatal.

Determines whether a safety finding should be escalated to a human pharmacovigilance officer

Route by escalation flag and priority: IMMEDIATE (escalate+P1), URGENT (escalate+P2), QUEUE (no escalate)

Regulatory decision: eu-rmp-module-router

Flywheel operational: evaluation-trend-predictor

Evans criteria signal classifier: PRR >= 2.0 AND chi_square >= 3.841 AND N >= 3.

Event aggregate traffic level: classifies overall safety status from counts of red and yellow events in a drug profile

Flywheel event flow health: GREEN (emitting>0 AND pending<100), YELLOW (emitting>0 AND pending>=100), RED (emitting=0)

Grade loop evaluation evidence quality for VDAG Reality Gradient.

Classifies evidence level based on study type and design characteristics

Domain 10: Grade evidence quality using GRADE-style hierarchy — from RCT meta-analysis down to expert opinion.

PDC: Validate L5+/L5++ executive impact metrics against quantitative thresholds

ICH E2A expectedness classification with severity dimension: EXPECTED_LISTED, EXPECTED_CLASS, UNEXPECTED_SEVERITY, or UNEXPECTED_NATURE

Regulatory decision: expedited-report-gate

ICH E2D / FDA 21 CFR 312.32 expedited reporting timeline: determines report type and deadline from case characteristics and study phase

Determines if an adverse event requires expedited reporting (ICH E2A).

Component: Shaft (External API) — Spec §2.4.

Routes FAERS queries to the appropriate endpoint strategy based on query type (drug, event, date_range, combination)

Assesses FAERS adverse event report quality.

Classify FAERS query results by report count and serious percentage into action categories

FDA abuse-deterrent opioid evaluation: routes by formulation properties and abuse pathway per FDA Guidance 'Abuse-Deterrent Opioids - Evaluation and Labeling' (2015)

FDA accelerated approval postmarketing requirements: routes by approval pathway and evidence status per FDA Guidance 'Labeling for Accelerated Approval' (2019) and PMR/PMC Annual Status (2023)

FDA structured benefit-risk assessment framework: routes 5-dimension evaluation to approval recommendation per FDA Guidance 'Benefit-Risk Assessment for New Drug and Biological Products' (2023)

FDA biosimilar safety study scope: determines comparative safety requirements by similarity level per FDA Guidance 'Biosimilar Comparative Analytical Assessment' (2025) and Interchangeability Guidance

FDA boxed warning determination: routes by risk severity and preventability per FDA Guidance 'Warnings and Precautions, Contraindications, and Boxed Warning Sections of Labeling' (2011) and 21 CFR 201.57(c)(1)

FDA clinical hold decision criteria: routes by hold basis and study phase per 21 CFR 312.42

FDA combination product postmarketing safety reporting pathway: routes by product type and lead center per FDA Guidance 'Postmarketing Safety Reporting for Combination Products' (2019)

FDA companion diagnostic codevelopment pathway: routes by therapeutic context and diagnostic status per FDA Guidance 'Developing and Labeling In Vitro Companion Diagnostic Devices' (2020)

FDA drug-induced liver injury evaluation: Hy's Law and DILI severity classification per FDA Guidance 'Drug-Induced Liver Injury: Premarketing Clinical Evaluation' (2009)

FDA Data Monitoring Committee action recommendation: routes interim safety signal to DMC action per FDA Guidance 'Establishment and Operation of Clinical Trial Data Monitoring Committees' (2006)

FDA drug interaction study requirement: routes by mechanism type and exposure change per ICH M12 'Drug Interaction Studies' (2024) and FDA DDI Guidance

ICH E19 selective safety data collection scope: routes by trial phase and prior data availability per ICH E19 'A Selective Approach to Safety Data Collection in Specific Late-Stage Pre-Approval or Post-Approval Clinical Trials' (2022)

FDA electronic safety report submission routing: determines format and gateway per FDA Guidance 'Providing Submissions in Electronic Format - Postmarketing Safety Reports' (2022) and FDA Regional Implementation Guide for E2B(R3) (2024)

FDA immunogenicity risk classification for therapeutic proteins: routes by product attributes and clinical impact per FDA Guidance 'Immunogenicity Assessment for Therapeutic Protein Products' (2014)

FDA medication error risk assessment: routes by error type and severity to risk mitigation per FDA Guidance 'Safety Considerations for Product Design to Minimize Medication Errors' (2016)

Regulatory decision: fda-medwatch-gate

FDA nitrosamine impurity acceptable intake limit routing: determines AI limit by compound type per FDA Guidance 'Recommended Acceptable Intake Limits for Nitrosamine Drug Substance-Related Impurities' (2023)

ICH S11 nonclinical pediatric safety testing requirements: routes by age group and clinical need per ICH S11 (2021) and FDA implementation

FDA OTC postmarketing adverse event reporting obligations: routes by product status and seriousness per FDA Guidance 'Postmarketing AE Reporting for Nonprescription Human Drug Products Marketed Without an Approved Application' (2009) and Dietary Supplement and Nonprescription Drug Consumer Protection Act (2006)

FDA periodic safety report type selector: routes by product lifecycle stage and regulatory requirements per FDA Guidance 'Providing Postmarket Periodic Safety Reports in the ICH E2C(R2) Format' (2016) and E2C(R2) Q&A (2016)

ICH E11A pediatric extrapolation decision tree: determines study requirements by disease similarity and PK comparability per ICH E11A 'Pediatric Extrapolation' (2024)

FDA postmarketing study obligation router: classifies PMR vs PMC and determines study type per FDA Guidance 'Annual Status Report for PMRs and PMCs' (2023) and 21 CFR 314.81

FDA pregnancy and lactation labeling decision tree: routes by data availability and risk level per FDA Guidance 'Pregnancy, Lactation, and Reproductive Potential: Labeling for Human Prescription Drug and Biological Products' (2015) and PLLR rule (21 CFR 201.57(c)(9))

FDA QTc prolongation risk classification: routes by QTc change magnitude to risk category and labeling action per ICH E14 (2017 R3) and FDA Guidance 'QTc Information in Prescription Drug Labeling' (2025)

FDA REMS modification decision tree: determines when a REMS requires modification based on safety signal type and evidence strength per FDA Guidance 'REMS Modifications and Revisions' (2019)

FDA real-world data source fitness: evaluates EHR, claims, and registry data quality dimensions per FDA Guidance 'RWD: Assessing EHR and Medical Claims Data' (2024)

FDA real-world evidence study fitness assessment: routes by RWD source and study design to regulatory acceptability per FDA Guidance 'Considerations for the Use of RWD and RWE' (2023)

FDA safety labeling change decision tree: routes by evidence type and labeling section per FDA Guidance 'Safety Labeling Changes - Implementation of Section 505(o)(4)' (2013)

FDA sponsor IND safety reporting assessment: determines reporting obligation from event characteristics per FDA Guidance 'Sponsor Responsibilities - Safety Reporting Requirements and Safety Assessment for IND and BA/BE Studies' (2025) and 21 CFR 312.32

Development gate: feature-flag-cleanup

Code hygiene gate: classifies source files by line count for single-pass readability.

Clinical safety: first-pass-effect

Pharmacokinetics: first-pass-metabolism assessment

Composite flywheel health gate combining event flow, velocity band, and tier coverage.

Flywheel operational: flywheel-maturity-level

Self-observation gate for the brain flywheel.

Combines session velocity, reality gate verdict, and momentum classification into unified flywheel health assessment.

Classify session development velocity from tool calls, commits, and files modified.

Follow-up urgency router: determines priority, deadline hours, and contact method for incomplete ICSR cases based on outcome, seriousness, and regulatory deadline proximity

Classifies the Ferro Forge quality_floor parameter from session success rate.

Loop 5 FlywheelVitals: Founder elastic equilibrium health classifier.

Flywheel friction drain classifier.

PVOS FSM history: filters state machine transition history relevance based on transition count and recency - ACTIVE/STALE/ARCHIVED

Master case processor: routes new cases through the complete PV workflow based on seriousness criteria, signal status, and causality state.

Management: detect competency gaps — given current level and target EPA, identify what domains need development.

Pharmacokinetics: genetic-polymorphism assessment

Pharmacokinetics: geriatric-pk assessment

Clinical safety: geriatric-risk-scorer

GI and hepatic safety classifier: maps digestive system adverse reactions using Hy's Law criteria for DILI and GI severity

Domain 13: Route to healthcare system model and PV integration approach by region — developed, emerging, resource-constrained.

Pharmacokinetics: glucuronidation assessment

PDC: Gate governance authority by tier — validates decision-maker competency level meets tier requirements

Cadena de enriquecimiento de causalidad desde gramática española.

Flywheel operational: growth-rate-classifier

Translates expedited-reporting chain outputs (report_type, timeline, days_from_awareness) into Guardian-compatible signal parameters (source, severity, pattern).

Flywheel gyroscopic stability classifier.

Clinical safety: half-life-classifier

Pharmacokinetics: half-life-elimination assessment

Translates harm classification and event traffic levels into signal priority dimensions.

Route ToV harm types A-H to response protocols based on the 8-type harm taxonomy

System health to traffic level mapper: converts health status string to traffic level for PV operations dashboard

Helix Computing decision tree — encode any system through the conservation law ∃ = ∂(×(ς, ∅)).

Run the helix system health chain: heligram verification → crystalbook 4-primitive check → crystalbook 8-law validation.

Pharmacokinetics: hepatic-clearance assessment

Pharmacokinetics: hepatic-impairment-pk assessment

Clinical safety: hepatotoxicity-screen

End-to-end HEXIM1 hypothesis validation chain.

Campion Signal Theory: S = U x R x T.

PDC: Human-in-the-Loop gate — classify actions as AUTO (agent decides), REVIEW (human reviews output), APPROVE (human must pre-approve)

Multi-organ homeostasis disruption scorer: aggregates organ system involvement count to detect multi-organ failure patterns

Flywheel operational: hook-effectiveness-gate

Endocrine stimulus-response router: maps stimulus category and intensity to hormone response and behavioral modulation using stem-bio SCIENCE model

Component: Hub (Nucleus) — Spec §2.2.

Code hygiene action router: takes file-size-gate and module-complexity-gate outputs and recommends action priority.

Information Component (IC) Bayesian disproportionality signal gate.

ICH E1 Population Exposure decision tree.

Regulatory decision: ich-e2a-seriousness

Regulatory decision: ich-e2c-periodic

Regulatory decision: ich-e2d-post-approval

Determines PBRER/PSUR reporting period based on ICH E2E guideline.

Regulatory decision: ich-e2e-pv-planning

Regulatory decision: ich-m1-regulatory-info

Regulatory decision: ich-q1-stability-gate

ICH Q1A(R2) Stability Testing decision tree.

ICH Q1B Photostability Testing decision tree.

Regulatory decision: ich-q2-analytical-gate

Score ICSR case completeness against ICH E2B(R3) minimum criteria.

ICSR case intake: classify drug reaction by signal strength, seriousness, causality, and route to appropriate deadline

Domain 4: Full ICSR processing workflow — intake through submission.

Pharmacokinetics: im-injection-pk assessment

Evaluate whether a pending immunity proposal should be promoted to antibody, dismissed as stale, or deferred for more evidence

Clinical safety: immunogenicity-risk

Immunogenicity risk classifier: maps immune-mediated adverse reactions including anaphylaxis, autoimmune conditions, and immunosuppression

PDC: Route to implementation approach based on organizational context and learner profile

NexCore incidence rate verification gate: determines whether a computed incidence rate meets NexCore verification standards based on denominator confidence, boundary level, and stream count

Domain 15: Route to information source type by data need — literature, regulatory databases, RWD, social media, genomic, digital health.

Pharmacokinetics: inhalation-pk assessment

Domain 12: Assess inspection readiness and route to preparation action by finding risk level and timeline.

Router: routes completed intake cases to the appropriate triage pathway based on validity, duplicate status, and data completeness

Doctrine integration coverage classifier.

PDC: Domain 1 cross-domain integration pathways — which domains D1 enhances, EPA connections, CPA support

Domain 10 cross-domain integration — benefit-risk assessment connects to communication, signal detection, risk management, and research.

Domain 11 cross-domain integration — risk management connects to benefit-risk, communication, error prevention, signal detection, and regulatory.

Domain 12 cross-domain integration — regulatory connects to quality/research, risk management, communication, and global PV.

Domain 13 cross-domain integration — global PV connects to communication, risk management, regulatory, and information sources.

Domain 14 cross-domain integration — communication amplifies every other domain.

Domain 15 cross-domain integration — information management enables evidence-based practice across all domains.

Domain 2 cross-domain integration — clinical ADR expertise enhances which domains, EPA connections, CPA support.

Domain 3 cross-domain integration — enhanced coverage domain, 50% EPA integration requirement.

Domain 4 cross-domain integration — ICSR processing enhances case quality, signal detection, compliance, and AI development.

Domain 5 cross-domain integration — enhanced coverage domain, clinical trial safety connects to regulatory, signal detection, benefit-risk.

Domain 6 cross-domain integration — enhanced coverage domain completing the triad (D3+D5+D6).

Domain 7 cross-domain integration — spontaneous reporting systems connect to signal detection, case processing, literature, and global PV.

Domain 8 cross-domain integration — signal detection connects to databases, literature, clinical assessment, benefit-risk, and global PV.

Domain 9 cross-domain integration — post-authorization research connects to signal detection, databases, clinical trials, and benefit-risk.

Routes drug-drug interaction characteristics to signal hypothesis and priority

Domain 11: Evaluate risk management intervention effectiveness — process indicators, outcome indicators, and optimization actions.

Pharmacokinetics: intrathecal-pk assessment

Transbeyesian class propagation → EIG priority ranking.

Determines if an AI agent should initiate a formal safety investigation based on signal detection and case seriousness

Pharmacokinetics: iv-bolus-pk assessment

Fills the λ (Location) primitive gap.

Detects when a FAERS signal exists for a drug-event pair but the event is NOT on the drug current label

Evaluates drug label completeness for safety assessment.

Routes DailyMed SPL label queries to the correct section ID, name, and PV relevance tier

Routes adverse event from label status to expectedness classification

Determine which VDAG learning loop to activate based on failure rate and evaluation count.

Session lesson triage router.

PDC: Return full level characteristics — knowledge state, skill application, behavioral indicators, AI integration, assessment method

PDC: Gate competency level (1-7) into progression tier with behavioral anchor requirements

PVOS entity lifecycle: classifies current lifecycle state and routes to appropriate action for new/active/suspended/archived entities

Routes literature findings into signal hypothesis and recommended actions

Station operations: load-balance-health

Pharmacokinetics: loading-dose-calc assessment

Flywheel loop interaction hierarchy (Spec Section 4).

Loop Governor: transforms scorecard-compound governor signals into loop control.

Lymphatic safety classifier: maps lymphoproliferative and haematologic adverse reactions to severity grades

Pharmacokinetics: maintenance-dose-calc assessment

MaxSPRT (maximized sequential probability ratio test) gate for sequential signal surveillance.

Decide action for stale MCP server binary.

Domain 4: MedDRA hierarchy level router — SOC, HLGT, HLT, PT, LLT.

Regulatory decision: meddra-level-classifier

MedDRA coding level selector: determines which hierarchy level (LLT/PT/HLT/HLGT/SOC) to use based on coding purpose and context

Classifies adverse event severity based on MedDRA SOC, fatality status, seriousness criteria (hospitalization, fatality).

Development gate: memory-usage-gate

Pharmacokinetics: metabolite-activity assessment

Run any microgram by name with JSON input.

Development gate: migration-readiness

Loop 4 FlywheelVitals: Gyroscopic stability inputs.

Code hygiene gate: classifies Rust modules by public function count.

Module→Loop mapping from Spec §5.

Chemistry-based molecular safety screening: evaluates molecular weight, heavy atom count, bond saturation, and charge to gate drug candidates using prima-chem molecular primitives

Angular momentum classifier for flywheel conservation law.

Detect flywheel momentum from current vs previous velocity (ms).

Multi-omics convergence gate for biomarker validation.

Combines PRR, ROR, IC, and EBGM signal classifications into an overall pharmacovigilance signal assessment.

Rank 4 PV signal measures (PRR, ROR, IC, EBGM) against each other using cross-variable comparison.

Acute multi-signal storm detector: classifies serotonin syndrome, neuroleptic malignant syndrome, and malignant hyperthermia

Musculoskeletal safety classifier: maps muscular adverse reactions to severity grades for rhabdomyolysis, myopathy, and tendon disorders

Quick Naranjo causality assessment from a score.

Gate 5 of narrative safe-extract: verify redacted narrative retains sufficient clinical content for regulatory value per ICH E2B(R3) minimum data elements

Gate 3 of narrative safe-extract: assess re-identification risk from quasi-identifiers (rare disease + age + region combinations) per ICH E2B(R3) and HIPAA expert determination

Gate 1 of narrative safe-extract: detect direct PHI elements (names, dates, addresses, phone numbers, medical record numbers) in ICSR narrative fields per HIPAA Safe Harbor 18 identifiers

Gate 4 of narrative safe-extract: route narrative through redaction decision based on combined PHI severity, site exposure, and inference risk to produce a final extract/block/review verdict

Gate 2 of narrative safe-extract: detect clinical trial site identifiers, institution names, and investigator details that could compromise trial blinding or reveal proprietary relationships

Clinical safety: nephrotoxicity-screen

Neurological safety classifier: maps nervous system adverse reactions to severity grades including PML, seizures, and neuropathy

NexCore verification pipeline: chains boundary-threader -> denominator-confidence -> incidence-verifier to produce a verified NexCore stamp for any drug-event-boundary combination

Management: given current level and career goal, recommend the single next development action.

Routes the next step in a PV investigation workflow based on current progress and blockers

Flywheel node readiness gate: READY (loop_closure>=0.5 AND compounding>=0.5 AND automation>=0.2), WIRING (any>=0.3), DORMANT (all<0.3)

Pharmacokinetics: obesity-pk assessment

Org Health metric OH-01 metric CQ-01

Org Health metric OH-02 metric CQ-01

Org Health metric OH-03 metric CQ-01

Org Health metric OH-04 metric CQ-01

Org Health metric OH-05 metric CQ-01

PV onboarding readiness gate: evaluates completion percentage and quiz performance to classify user as ready/almost/needs_work/beginner for independent PV tool usage

Pharmacokinetics: ophthalmic-pk assessment

Domain 3: Route ADR by affected organ system — hepatic, cardiovascular, neurological, hematological, immunological.

Classify FAERS outcome codes into ICH E2A seriousness criteria with regulatory urgency.

Station operations: output-format-validator

Pharmacokinetics: p-gp-substrate assessment

Station operations: parameter-coverage

PDC: Route professional to development pathway based on experience and career goal

Nash payoff tier: classifies game theory payoff value into display tier for war-game dashboard

Regulatory decision: pbrer-section-classifier

PBRER section completeness gate: evaluates whether an ICH E2C(R2) section has sufficient data to be considered complete, partial, or missing

PDC Program Effectiveness metric PDC-01

PDC Program Effectiveness metric PDC-02

PDC Program Effectiveness metric PDC-03

PDC Program Effectiveness metric PDC-04

PDC Program Effectiveness metric PDC-05

PDC Program Effectiveness metric PDC-06

PDC Program Effectiveness metric PDC-07

PDC Program Effectiveness metric PDC-08

PDC Program Effectiveness metric PDC-09

PDC Program Effectiveness metric PDC-10

Program Excellence PE-01 metric PDC-01

Program Excellence PE-02 metric PDC-01

Program Excellence PE-03 metric PDC-01

Program Excellence PE-04 metric PDC-01

Program Excellence PE-05 metric PDC-01

Program Excellence PE-06 metric PDC-01

Program Excellence PE-07 metric PDC-01

Program Excellence PE-08 metric PDC-01

Program Excellence PE-09 metric PDC-01

Program Excellence PE-10 metric PDC-01

Program Excellence PE-11 metric PDC-01

Program Excellence PE-12 metric PDC-01

Pharmacokinetics: peak-level-check assessment

Clinical safety: pediatric-dosing-gate

Pediatric PV flag: NEONATAL_FLAG for age <2, PEDIATRIC_URGENT for age <12 with developmental impact, PEDIATRIC_REVIEW for unlabeled pediatric use, STANDARD otherwise

Pharmacokinetics: pediatric-pk assessment

Pediatric age-based safety routing per ICH E11: classifies developmental stage, dose check requirement, and escalation for serious adverse events in minors

Regulatory decision: periodic-report-classifier

Guardian wire for Failure Mode #7 (Perspective Collapse).

Routes a perturbation pattern to the appropriate evaluation strategy based on boundary data availability.

Classifies pharmacovigilance observations into the 6-layer perturbation pattern model.

Evaluates whether a safety analysis approach uses the three architectural innovations that distinguish the perturbation pattern framework from existing QSP/AOP/network pharmacology.

Classifies a company's competitive position in FAERS relative to a named competitor.

Head-to-head comparison of two pharmaceutical companies based on FAERS data.

Routes a pharmaceutical company to a portfolio tier based on pipeline size.

Classifies a pharmaceutical company's FAERS signal volume tier.

Pharmacokinetics: phase1-oxidation assessment

Pharmacokinetics: phase2-conjugation assessment

Clinical safety: photosensitivity-flag

Pharmacokinetics: placental-transfer assessment

PMR/PMC compliance status classifier: maps status, due date, and days overdue to on_track/at_risk/delayed/critical classification with recommended action

Polypharmacy risk assessment: HIGH_RISK if >5 drugs + interaction + elderly, MODERATE_RISK for intermediate combinations, LOW_RISK otherwise

Aggregates patient population risk factors from special-population, pediatric-flag, and polypharmacy-risk into unified risk profile.

Portfolio risk tier classification: maps signal_count and signal_ratio to critical/high/medium/low tiers for drug portfolio monitoring

Development gate: pr-size-classifier

Clinical safety: pregnancy-category

Pregnancy exposure categorization and reporting requirements per ICH E2C/FDA guidance: trims risk level and mandates reporting based on teratogen status and outcome

Pregnancy exposure and teratogenicity classifier: maps reproductive adverse reactions to severity grades per FDA pregnancy categories and ICH S5(R3)

Pharmacokinetics: pregnancy-pk assessment

Desambigua formas verbales españolas entre indicativo y subjuntivo usando el verbo rector como árbitro.

NER-PIM: Classifies system behaviors by T1 primitive composition.

Law of Primitive Succession: identify dominant primitive of a system and predict its successor.

Pharmacokinetics: prodrug-activation assessment

PDC: Route program type by entry level and duration to exit level range

Flywheel operational: promotion-gate-composite

Pharmacokinetics: protein-binding-affinity assessment

Clinical safety: protein-binding-risk

Station operations: proxy-health-check

Quantumizing regulator: collapses continuous PRR magnitude into discrete triage actions.

Classify a PRR value as signal/no-signal using Evans (2001) criteria.

PRR signal strength: classifies PRR value into strength tier for drug safety assessment display

Patient Safety metric PS-01 metric CQ-01

Patient Safety metric PS-02 metric CQ-01

Patient Safety metric PS-03 metric CQ-01

Patient Safety metric PS-04 metric CQ-01

Patient Safety metric PS-05 metric CQ-01

Periodic Safety Update Report (PSUR) submission interval based on post-approval duration and special conditions.

Regulatory decision: psur-signal-router

Filters PubMed articles for pharmacovigilance relevance.

Pulmonary safety classifier: maps respiratory adverse reactions to severity grades for ILD, pulmonary fibrosis, and respiratory failure

Academy Level 1 teaching exercise: tests whether a learner can identify perspective divergence in PV safety terms.

Perspective divergence detector: flags terms where author and reader hold different boundaries for the same word.

Orchestrator: routes a drug-event pair through the 5-stage PV loop (Detect → Evaluate → Assess → Act → Monitor) and determines feedback triggers for loop re-entry

Run the core PV workflow chain: PRR signal detection → causality bridge → Naranjo assessment → regulatory action routing.

PVOS threshold calibration: gates algorithm threshold calibration on minimum sample size (>=100) and feedback count (>=10) - prevents calibration on sparse data

PVOS signal detection: routes detection request to the appropriate algorithm (PRR/ROR/IC/EBGM/Chi2/Fisher) based on algorithm selection and contingency table availability

Clinical safety: qtwas-prolongation-risk

PDC: Classify framework element as CORE (globally immutable) or FLEXIBLE (culturally adaptable)

Classify code quality score: PASS (>=80), WARN (>=60), FAIL (<60)

Station operations: rate-limit-status

Domain 6: Route to appropriate root cause analysis method by error complexity and investigation scope.

VDAG Reality Gradient gate: APPROVED (>=50), WARN (>=20), BLOCKED (<20 = testing theater)

Rechallenge rate evaluator using cross-variable comparison: compares baseline_rate, first_exposure_rate, and rechallenge_rate to assess Bradford Hill experiment criterion.

Flywheel operational: recovery-estimator

PDC: Route to regional implementation considerations — APAC, Europe, Americas, Emerging Markets

Predicts likely regulatory action based on cross-domain safety evidence

Translates regulatory assessment outputs into case intake fields.

Domain 12: Route to regulatory submission pathway by product type, urgency, and therapeutic designation.

Routes regulatory decisions to corresponding label update actions

Development gate: release-readiness

FDA REMS type classifier: determines Risk Evaluation and Mitigation Strategy requirements per 21 CFR 314.520

Pharmacokinetics: renal-clearance assessment

Pharmacokinetics: renal-impairment-pk assessment

Renal safety classifier: maps kidney adverse reactions to severity grades using KDIGO AKI staging and nephrotoxicity signals

Determine regulatory reporting deadline based on seriousness and expectedness

Classify reporter by type and derive qualification level, causality weight, and MedWatch submission eligibility.

Classify FAERS reporter type into quality weight for signal assessment.

Routes serious adverse event reports to appropriate regulatory authorities based on occurrence location, marketing authorization, seriousness, and urgency.

Master priority calculator combining seriousness + expectedness + causality per ICH E2A.

Fills the ν (Frequency) primitive gap.

Domain 4: Regulatory reporting timeline by jurisdiction and event type — FDA, EMA, PMDA, Health Canada deadlines.

Gates API response based on result count and error status.

Validates API response data freshness.

Station operations: response-time-classifier

Station operations: retry-policy

Flywheel rim structural integrity classifier.

PDC competency assessment: risk-categorization proficiency classifier

PDC: Classify detected risk by category and severity, route to response team and protocol

PDC competency assessment: risk-communication proficiency classifier

ToV harm taxonomy classifier: maps a 0-100 composite risk score to harm levels A through F with plain-English descriptions and traffic level

PDC competency assessment: risk-identification proficiency classifier

PDC competency assessment: risk-monitoring proficiency classifier

PDC competency assessment: risk-quantification proficiency classifier

Classify risk score 0-100 into CRITICAL/HIGH/MODERATE/LOW bands for Guardian risk routing

Router: routes risk management decisions to the appropriate regulatory submission action based on market action, benefit-risk verdict, and labeling needs

Risk Minimization Plan (RMP) measure effectiveness assessment based on measure type, compliance rate, and outcome improvement.

Regulatory decision: rmp-measure-selector

Domain 11: Route to risk minimization measure type by risk severity, population scope, and regulatory requirement.

Station operations: rollback-readiness

Reporting Odds Ratio (ROR) signal detection threshold gate.

Railway Reference Model capacity calculator.

Railway Reference Model (RRM) layer classifier.

Railway Reference Model monitoring level classifier.

Railway Reference Model SIL assigner.

RUCAM hepatotoxicity causality classification from total score

Classify a safety margin distance value (d) into DANGER/CAUTION/SAFE zones with corresponding score ranges

Assesses completeness of cross-domain safety profile data

Classifies the type of regulatory variation needed for safety-related changes.

Station operations: schema-version-check

Compound Scorecard: aggregates session-level product chain scores into multi-scale verdicts.

Domain 15: Route to search strategy approach by urgency, comprehensiveness requirement, and available resources.

Flywheel operational: sensor-actuator-rebalance

Clasifica síntomas clínicos en español por temporalidad usando la distinción gramatical ser/estar.

ICH E2A seriousness classification → boolean decomposition → deadline routing.

Routes case seriousness level to expedited reporting requirements

Auto-generated DAG from session 7baa8d07 fast-food prompts (3 nodes)

Auto-generated DAG from session 85562588 fast-food prompts (3 nodes)

Chain: routes session activities through primitive-recognizer to produce a session primitive profile.

Apnea — the productive hold between inhale and exhale.

T Tauri χ health classifier: maps branching ratio χ = output/input to health band using equilibrium boundaries from Serna et al.

Start codon — assess session readiness from carry-forward state, arc position, helix debt, and active bonds.

Score a Claude Code session across 5 KPI dimensions — velocity, efficiency, quality, tooling depth, and outcome — producing a composite session health score and business value indicator

Decision DAG for fast-food session prompts.

Flywheel operational: session-quality-scorer

Product Chain Scorecard: scores a session (or any work unit) on how far it advanced through the T1 primitive product chain.

Flywheel operational: session-spacing-classifier

Session productivity velocity classifier.

Classify severity into tiers: CRITICAL (>=90), HIGH (>=70), MEDIUM (>=40), LOW (<40)

Strategic Goal metric SG-01 metric CQ-01

Strategic Goal metric SG-02 metric CQ-01

Strategic Goal metric SG-03 metric CQ-01

Bridge: PRR signal + Naranjo causality → action urgency.

Combines PRR signal detection, Evans criteria, and trend analysis into composite signal confidence.

PDC competency assessment: signal-closure proficiency classifier

Campion Signal Theory S = U × R × T collapse gate.

PDC competency assessment: signal-communication proficiency classifier

Cross-signal comparator: compares two PV signals (PRR values) and determines which is stronger, whether they agree, and if their ratio suggests confounding.

Merges signal detection output (signal_detected, prr, classification) with case assessment output (serious, unexpected, report_type) into a unified compliance action.

End-to-end chain: 4-measure disproportionality consensus → signal-to-causality routing → Naranjo causality assessment → regulatory action with ICH E2B deadlines.

Signal count to traffic level: maps the number of positive signal algorithms (0-5) to a traffic level for display

Multi-dimensional signal quality assessment.

Routes a drug through the full signal detection pipeline: classifies signal strength from PRR/ROR/case_count or routes to FAERS lookup

PDC competency assessment: signal-escalation proficiency classifier

Routes accumulated signal intelligence to appropriate next action based on signal count, cross-drug overlap, and insight maturity.

Domain 8: Route to signal detection method by data type, sample size, and analytical goal — PRR, ROR, IC, EBGM, ML, NLP.

PDC competency assessment: signal-prioritization proficiency classifier

Domain 8: Prioritize validated signal by public health impact, severity, frequency, and vulnerable population risk.

Determines if multiple data sources agree on a safety signal and quantifies agreement strength

Signal level to strength mapper: converts traffic level (red/yellow/green) to signal strength label for dashboard display

Bridge: routes signal detection results to causality assessment recommendation.

Router: routes confirmed signals into risk management actions based on signal strength, causality, and product lifecycle stage

Routes signal detection results to Risk Minimization Plan update decisions

Detects signal trend direction from pre-computed change percentage.

PDC competency assessment: signal-validation proficiency classifier

Signal validation gate: counts confirmed criteria (PRR threshold, case count, geographic spread, temporal pattern) to classify signal strength

Primitive Collider: takes two microgram primitive signatures and predicts the resultant signature when chained.

algovigilance site development strategy router.

ALG-2025-029 SMI Drift Detection.

Maps severity bands to credibility levels for empirical works (SMM-001 path).

NVG-SMM-001 Section 5: Compute Credibility Score from violation counts.

First gate in SMM chain.

Terminal node in SMM chain.

NVG-SMM-001 Sections 5-6: Final integration gate — applies evidence weight, K-bias checks, and uncertainty propagation.

Maps severity bands to maturation levels for pre-empirical frameworks (SMM-002 path).

NVG-SMM-001 Section 3: Audit a scientific method phase for documentation compliance.

NVG-SMM-001 Section 5.2: Map Credibility Score to rating and integration disposition.

Routes scientific works to the correct evaluation standard (SMM-001 for empirical, SMM-002 for pre-empirical).

NVG-SMM-001 Section 4: Classify epistemological violations by severity (F/C/M/m).

Classifies violation severity into bands approximating CS/MS formulas.

Decompose threshold authority into primitives — consensus breadth, credential strength, evidence basis, institutional backing — and score defensibility.

SOTA Tracker: classifies a PV domain and returns its threshold authority, comparison method, and current frontier definition

Guardian SOTA Tracker — detect frontier movement in a pharmacovigilance domain.

SOTA Tracker: evaluates whether a finding represents frontier movement in a PV domain based on evidence level and authority weight

PubMed → SOTA pipeline: triage a publication for frontier relevance, classify its PV domain, check frontier movement, and assess drift severity.

SOTA Tracker: triages a PubMed finding for frontier relevance based on article type, recency, and citation signals

Route to the weakest space surface for growth: CONFIG, MCG, ROUTE, or CRATE

Flywheel operational: space-surface-prioritizer

Detecta cambios de código español↔inglés en texto clínico y extrae señales de causalidad de los puntos de cambio.

Classifies the 6 Spanglish primitives — boundary phenomena that exist ONLY at the code-switch interface between Spanish and English.

Classifies English-to-Spanish cognate confidence based on morphological features

Classifies Spanish verb conjugation difficulty into tiers based on ending, regularity, and reflexivity

Decides whether the subjunctive mood is required based on sentence semantics using the WEIRDO mnemonic

Domain 2: Flag special population considerations for ADR assessment — pediatric, geriatric, pregnancy, renal/hepatic, immunocompromised.

Domain 7: Route to spontaneous reporting system by jurisdiction — FAERS, EudraVigilance, VigiBase, JADER, Canada Vigilance.

Station operations: ssl-cert-freshness

Clasifica la deriva de conteo como OK o DRIFTED.

Evalúa la fiabilidad efectiva de un dominio de confianza aplicando decaimiento exponencial.

PVOS state queries: routes FSM state queries to the correct entity repository (case/signal/workflow/alert)

Classify API availability: live proxy vs stub vs unknown

DailyMed ADR label data → risk tier → causality routing.

Route incoming question to correct regulatory/PV domain based on question type

DrugBank DDI data → interaction severity → causality routing.

Route to fallback domain when primary is unavailable

Gate: should this query hit multiple domains simultaneously?

OpenVigil disproportionality → signal triage → causality routing.

PubMed signal literature → evidence strength → causality routing.

FDA recall data → recall severity classification → regulatory action routing.

RxNav drug interaction data → interaction severity → signal routing.

Select specific tool name from domain and intent

Clinical trial SAE data → safety concern triage → causality routing.

Pharmacokinetics: steady-state-time assessment

Domain 9: Route to appropriate study design by safety question type, data availability, and evidence needs.

Pharmacokinetics: subcutaneous-pk assessment

Clasifica la confianza epistémica del hablante basándose en el modo verbal español (indicativo vs subjuntivo).

Pharmacokinetics: sulfation assessment

ICH E2A SUSAR classification: Suspected Unexpected Serious Adverse Reaction determination from seriousness, expectedness, and causality

Classify drug-event pair as Suspected Unexpected Serious Adverse Reaction.

Classify drug characterization from FAERS into causality weight.

Pharmacokinetics: sustained-release-pk assessment

System resource health classifier: RAM, swap, disk, cache.

Development gate: tech-debt-scorer

Assess temporal association between drug exposure and adverse event.

Clinical safety: teratogenicity-classifier

Development gate: test-coverage-gate

Classify test run: GREEN (0 failures), YELLOW (<=5% failure rate), RED (>5%)

Pharmacokinetics: therapeutic-drug-monitoring assessment

Clinical safety: therapeutic-index-classifier

Detect threshold drift from consecutive warnings/criticals and declining reality trend.

Station operations: throughput-classifier

Flywheel tier promotion gate: validates node can advance Draft→Staging→Live based on emitter count, test pass rate, and reality score

Station operations: timeout-calibration

Pharmacokinetics: tissue-penetration assessment

Station operations: tool-count-validator

Station operations: tool-schema-validator

Predicts next-action priority for algovigilance external traffic growth.

ALG-2025-022: Trajectory Centroid Calculator.

Transbeyesian belief propagator: computes cross-domain signal updates using shared primitive structure (transfer_weight) as the propagation channel.

Pharmacokinetics: transdermal-pk assessment

Transform: decomposes case-seriousness string + criterion into boolean flags (serious, fatal, life_threatening) for downstream mcgs

Station operations: transport-health

Routes trend analysis to communication action level determination

Router: routes triaged cases to signal detection, causality assessment, or periodic reporting based on seriousness and expectedness

Classifies clinical trial safety endpoint significance by trial phase and sample size

Routes serious adverse event classification to SUSAR determination and reporting timeline

Domain 5: Route clinical trial safety report by type — IND safety, DSUR, IB update, CSR.

Routes clinical trial safety data to signal detection and threshold evaluation

Pharmacokinetics: trough-level-check assessment

PVOS underreporting estimation: categorizes reporting completeness based on reported-to-expected case ratio

Development gate: unsafe-audit

Component: Rim (Value Network) — Spec §2.1.

Vascular safety classifier: maps circulatory adverse reactions to severity grades for thromboembolism, hemorrhage, and vascular disorders

Run the complete vehicle cascade: bioavailability correction → PRR signal detection → causality assessment → Naranjo scoring → regulatory action → organ health signal.

Run the governance cascade: KCL field balance → KVL loop conservation → reporting velocity governor.

Run the engine health cascade: primitive failure classifier → organ signal adapter.

Flywheel velocity classifier: ACCELERATING (nodes_wired_this_session>=2), STEADY (=1), STALLED (=0)

Classify flywheel velocity from avg_fix_time_ms matching MCP foundation_flywheel_velocity bands: EXCEPTIONAL (<=1h), TARGET (<=24h), ACCEPTABLE (<=168h/7d), SLOW (>168h)

Flywheel operational: verdict-rate-tracker

Routes DAG structure to visual representation format (Mermaid, ASCII, or dot) for notebook rendering

Pharmacokinetics: washout-period-calc assessment

Regulatory decision: who-umc-category

WHO-UMC causality assessment scale: international standard alternative to Naranjo, used in VigiBase/VigiAccess reporting

Clinical safety: withdrawal-syndrome

Determines whether the PV investigation workflow is complete and ready for closure

PVOS workflow definition: validates that a workflow definition has required steps (detect + report) and minimum length before registration

Route a PV case to the appropriate workflow based on case characteristics.

PVOS workflow gating: gates workflow start on valid workflow type and data readiness prerequisites

PVOS workflow status: classifies workflow execution status from step completion and failure flag - NOT_STARTED/IN_PROGRESS/COMPLETED/FAILED

Workspace health classifier: checks orphan_dirs, broken_members, and cache_gb against thresholds.

Evaluate a trained ML model on held-out test data.

Extract 12-element PV feature vector from FAERS 2x2 contingency table: PRR, ROR, IC, EBGM, log(cases), HCP ratio, consumer ratio, serious ratio, death ratio, hospitalization ratio, median time-to-onset, reporting velocity

Run the full autonomous ML pipeline end-to-end: ingest raw FAERS contingency data, extract 12 PV features, train random forest, evaluate on holdout set, and return predictions with metrics.

Predict signal probability for drug-event pairs using a trained ML model.

Train a random forest model on labeled PV feature data.

Compare Moderna Inc.

Get recent safety labeling changes for Moderna Inc.

Get Moderna Inc.

Get Moderna Inc.

Get Moderna Inc.

Get Moderna Inc.

Search Moderna Inc.

Map ADME pharmacokinetic phases to Prima computation lifecycle.

Map Central Dogma stages to Prima compilation phases.

Translate a single codon (3 nucleotides) to amino acid.

Translate mRNA sequence to protein string.

λ (location): Spatial distribution of signal concentrations

ρ (recursion): Internalized signal triggers recursive cascade processing

Get adaptive engine statistics.

the filtered verdict, actions, and learning events.

Process a verdict through the SMG degradation complex.

Nmd Status

Get thymic graduation status.

Raw UPF structural check only (no thymic/SMG/adaptive).

Batch drift detection across contracts.

Generate synthetic data from a stored contract's schema.

Ribosome List

Store a baseline contract from JSON data.

Validate data against a stored contract (drift detection).

Get synapse information by ID

Create or get a synapse by ID

List all synapses with optional filtering

Observe a learning signal on a synapse

Synapse Prune

Synapse Stats

Generate synthetic data from observed JSON.

Schema inference only — lightweight, no violations or fidelity.

Full pipeline: infer + merge + violations + fidelity.

Synthesize boundary violations from observed data.

Compare molecular weights of two concepts.

Compute molecular weight of a concept from primitive composition.

Get the full periodic table of T1 primitive atomic masses (16 entries) with Shannon entropy statistics.

Predict cross-domain transfer confidence from a primitive composition.

Fan-out safety assessment across all 11 regulatory agencies — FDA, EMA, Health Canada, PMDA, TGA, MHRA, Swissmedic, HSA, Medsafe, ANVISA, COFEPRIS.

Compare regulatory actions taken across jurisdictions — recalls, safety communications, labeling changes, RMPs.

Compute cross-jurisdictional concordance score for a drug-event signal.

Check which of the 11 regulatory agencies have data for a drug.

Track how a safety signal propagated across jurisdictions chronologically.

Compare molecular weights of two concepts.

Compute the molecular weight of a concept from its constituent primitives.

Mw Periodic Table

Predict transfer confidence from a molecular weight value.

Retrieve full records for a list of NCBI UIDs in various formats.

Find linked records across NCBI databases.

Search NCBI databases for UIDs matching a query.

Retrieve summaries for a list of NCBI UIDs.

Search then fetch FASTA records in one call.

Search then summarize in one call (faster than full fetch).

Get or display NexChat configuration.

Check NexChat readiness — API key configured, model available.

Nexchat Tools

Nexcore Assist

Nexcore Health

Add a notebook to the library.

types question, waits for response with 3-poll stability check.

Cleanup NotebookLM data — closes browser, deletes data dir contents.

Close a session.

Get health status — reports browser, auth, library, sessions.

Get library statistics.

Get details of a specific notebook.

List all notebooks in the library.

List all active sessions.

Clear auth data and re-authenticate with fresh Chrome profile.

Remove a notebook from the library.

Reset a session's chat history.

Search notebooks by keyword.

Set the active notebook.

after the user confirms they've logged in.

Update notebook metadata.

Get China pharmacovigilance and ADR reports

Get China drug recall and withdrawal actions

Get China regulatory classification and approval status

Get China drug safety alerts and communications

Search China drug registration database

Isolate a specific node from the network

Returns per-boundary classification, distance, and overall regime.

Return the default Bayesian-heavy weight configuration with calibration provenance.

Compare additive (legacy) and geometric (non-compensatory) risk scores side-by-side.

Compute non-compensatory risk score using weighted geometric mean.

Compare Novartis AG adverse event reporting vs a competitor using PRR from FAERS

Get recent safety labeling changes for Novartis AG products

Get Novartis AG clinical trial pipeline — active and recruiting trials by phase

Get Novartis AG approved product portfolio — brand names, generics, routes, pharmacologic classes

Get Novartis AG product recalls and enforcement actions from FDA

Get Novartis AG aggregate safety profile from FAERS — top adverse reactions, outcomes, products with most reports

Search Novartis AG products by keyword — drug name, condition, or therapeutic area

Compare Novo Nordisk A/S adverse event reporting vs a competitor using PRR from FAERS

Get recent safety labeling changes for Novo Nordisk A/S products

Get Novo Nordisk A/S clinical trial pipeline — active and recruiting trials by phase

Get Novo Nordisk A/S approved product portfolio — brand names, generics, routes, pharmacologic classes

Get Novo Nordisk A/S product recalls and enforcement actions from FDA

Get Novo Nordisk A/S aggregate safety profile from FAERS — top adverse reactions, outcomes, products with most reports

Search Novo Nordisk A/S products by keyword — drug name, condition, or therapeutic area

Compute an AE signal heatmap from drug signal data.

Fab/Fc fragment mapping, and disulfide bond detection.

Compute bipartite drug-AE network layout from a VDAG definition.

Generate bounds visualization SVG.

Supports degree, betweenness, closeness, eigenvector, or all four.

the modularity score Q.

Generate confidence propagation waterfall SVG.

Generate 3D molecular coordinates via distance geometry.

Generate DAG topology visualization SVG.

Run a molecular dynamics simulation and return trajectory summary.

Compute molecular force field energy breakdown.

Run force-directed graph layout (CPU-side Fruchterman-Reingold / ForceAtlas2).

Construct a hypergraph and compute metrics, components, bipartiteness.

interaction details.

Select Level-of-Detail representation level based on atom count.

and sample surface points with normals and curvature.

Generate science/chemistry/math loop SVG.

Run energy minimization on a molecular structure.

for a chemical element symbol.

Viz Node Confidence

and optionally the overlap matrix.

Get a particle system preset configuration (solvent, reaction, electron).

Klein bottle, Clifford torus) and project it.

contact map, hydrogen bonds, radius of gyration, and aggregate metrics.

and generate WGSL shader source code.

power iteration.

Generate STEM taxonomy sunburst SVG.

optionally nodes/antinodes for a specific mode.

and returns vertex/triangle counts plus a mesh summary.

theorem on a triangle mesh.

Generate type composition diagram SVG.

and produce 3D layout coordinates.

Compare disproportionality scores between two drugs for the same adverse event

Compute PRR, ROR, and IC for a drug-event combination using FAERS data

Get demographic breakdown of cases for a drug-event pair

Get patient outcome distribution — death, hospitalization, life-threatening for seriousness assessment

Get annual reporting trends for a drug-event combination — detect emerging signals

Get top drugs associated with a specific adverse event

Get top adverse reactions for a drug ranked by disproportionality score

Retrieve full OpenAlex metadata for a single work by DOI.

Find authors by name with disambiguation metadata.

Search the OpenAlex works graph by free-text query.

Search medical device adverse event reports (MDR).

Openfda Device Recalls

Search drug adverse event reports from FAERS.

Search drug product labels (SPL).

Search National Drug Code directory.

Search drug recall enforcement actions.

Search Drugs@FDA applications (NDA/BLA/ANDA).

Fan-out search across all major OpenFDA endpoints simultaneously.

Search food adverse event reports (CAERS).

Search food recall enforcement actions.

Search FDA substance registry.

Disease profile — EFO ID, ontology, top associated targets with evidence scores

Drug profile — ChEMBL ID, mechanism of action, indications, max clinical phase, withdrawn/black-box status

FAERS-derived significant adverse events for a drug, with log-likelihood ratio disproportionality scores

Full target profile — approved symbol, biotype, subcellular location, tractability, safety liabilities

Diseases associated with a target, ranked by Open Targets overall association score (genetic, somatic, drug, pathway, literature evidence)

Known safety liabilities for a target — organ systems, mechanism categories, literature citations

Universal search across targets (genes/proteins), drugs, and diseases

drift from stable — `Result::is_ok()` is always true for well-formed inputs.

distributions; near 1 indicates maximally different.

(max CDF difference) and approximate p-value.

> 0.25: Significant shift (action required)

`monitoring_alerts` — filtered alert list by severity.

Monitoring Health Check

`monitoring_hook_health` — deep analysis for a specific hook or all hooks.

`monitoring_signal_digest` — signal groups by type/priority.

a maximum acceptable age (SLA).

for a specific endpoint or all endpoints.

Observability Record Latency

Check if an IP address would be whitelisted by sentinel.

Return annotated default configuration with descriptions for each field.

Parse a syslog auth line into a structured AuthEvent.

Sentinel Status

Ingest an event sequence to teach the Oracle transition patterns.

Record what actually happened after a prediction (feeds accuracy tracker).

Predict the next event given the current state.

Get the Oracle's accuracy report and calibration status.

Reset the Oracle (start fresh with optional config).

Get Oracle status (quick overview).

Get top-N predictions from a state (with optional 2nd-order context).

Classify a natural language PV query into a workflow category: signal_detection, causality_assessment, regulatory_reporting, case_processing, benefit_risk, literature_review, competitive_analysis.

Given a pharmacovigilance objective, decompose it into ordered steps and identify which tools to call at each step.

Take raw PV data (signal scores, causality results, regulatory determinations) and produce a structured safety narrative suitable for a PSUR, DSUR, or internal safety review.

Run the full ORGANIZE pipeline in analysis (dry-run) mode.

Return default ORGANIZE configuration for a directory.

Run the observe step only — inventory filesystem entries with metadata.

Run observe + rank steps — inventory and score entries by recency/size/relevance.

Run ORGANIZE pipeline and return a JSON report.

Run ORGANIZE pipeline and return a markdown report.

Classify atoms into hierarchy positions via chromatographic separation.

Distill a regulatory expression into atoms ordered by volatility.

Prove semantic equivalence between two regulatory expressions.

Get registry statistics — atom count by class and total.

Titrate an expression against canonical standards to measure meaning coverage.

Generate code from Prima source for a target language.

Evaluate a Prima expression and return the result.

Parse Prima source code and return AST as JSON.

Analyze Prima source and list the T1 primitives used.

Prima Targets

Get the disease name from an Orphanet detail page by ORPHA code.

Get the HTML <title> of an Orphanet disease page.

Competitive intelligence with domain-filtered search.

Regulatory intelligence pre-filtered to FDA/EMA/ICH/WHO domains.

High-level research routing by use case (general, competitive, regulatory).

Search documents by query string

Compare Pfizer Inc.

Get recent safety labeling changes for Pfizer products

Get Pfizer clinical trial pipeline — active and recruiting trials by phase

Get Pfizer approved product portfolio — brand names, generics, routes, pharmacologic classes

Get Pfizer product recalls and enforcement actions from FDA

Get Pfizer aggregate safety profile from FAERS — top adverse reactions, outcomes, products with most reports

Search Pfizer products by keyword — drug name, condition, or therapeutic area

Useful for safety surveillance and competitive black-box analysis.

Classify a set of generators into a Chomsky hierarchy level.

communications.

Look up transfer confidence for a pharma primitive to a target domain.

Omitting `phase` returns all candidates.

Get info about a specific R&D pipeline stage.

accumulated across its entire portfolio?"

Get the top N strongest cross-domain transfer corridors.

Get Lex Primitiva symbol coverage across the R&D pipeline.

Get the full pharma R&D taxonomy summary (concept counts by tier).

Get the full transfer confidence matrix (all primitives x all domains).

Get the bottom N weakest cross-domain transfer corridors.

Calculate Area Under the Concentration-Time Curve using linear or log-linear trapezoidal method.

Calculate systemic clearance from dose and AUC.

Calculate elimination half-life from clearance and Vd.

Calculate Michaelis-Menten saturation kinetics.

Calculate average steady-state concentration.

Retrieve a specific or latest PHAROS surveillance report.

Run full L1-L5 validation

Check PHAROS status: existing reports, timer state.

Phase IV post-marketing surveillance verdict with auto-escalation.

Generate mutations of a JSON input for adversarial testing.

Verify schema compatibility between original and mutated JSON.

Batch compute disproportionality metrics for multiple drug-event pairs.

a 2x2 contingency table.

Detect a signal for a drug-event pair with configurable thresholds.

Get the crate's T1 primitive manifest.

Get the PV pipeline relay chain with fidelity per stage.

Generate a signal detection report from batch data.

Get threshold configurations (Evans, strict, sensitive).

Look up cross-domain transfer mappings for signal-pipeline types.

Validate a detection result against multiple quality checks.

Get disease associations for a target with evidence scores

Get drug evidence linking a target to a disease

Get pharmacogenomics evidence for a target

Get known safety effects and toxicity for a target

Search diseases by name or EFO identifier

Search for drug targets by gene name or protein

Search Japanese adverse drug reaction case reports

Get Japanese drug approval information including review reports

Get post-marketing re-evaluation results

Get Risk Management Plan summary for a Japanese-approved drug

Search PMDA adverse drug reaction relief system cases

Search PMDA safety communications and Dear Healthcare Professional letters

Get Indonesia pharmacovigilance and ADR reports

Get Indonesia drug recall and withdrawal actions

Get Indonesia regulatory classification and approval status

Get Indonesia drug safety alerts and communications

Search Indonesia drug registration database

Compute Casimir extractable energy for parallel plate geometry.

Classify a physical transducer by energy domain mapping (mechanical/thermal/optical/chemical/electromagnetic/acoustic/nuclear → electrical/mechanical/thermal/optical/acoustic).

State-of-Charge estimator using fused EKF + OCV + coulomb counting.

Evaluate bus voltage topology for wearable/vehicle power systems.

The 10^120 vacuum energy discrepancy — worst prediction in physics.

Route power demand to the correct energy tier in a federated battery architecture.

Schedule per-limb buffer charging from main bus.

Full three-tier evaluation: runs reactive, predictive, AND preemptive detection in one call.

Tier 3: Preemptive detection via Gibbs free energy thermodynamic model.

Model competitive inhibition intervention: compute residual signal after applying an intervention of given strength.

Noise floor correction: compute corrected signal by subtracting background noise and testing statistical significance.

Reference table of all seriousness omega weights used in predictive and preemptive tiers.

Tier 2: Severity-weighted predictive detection.

Tier 1: Standard reactive signal detection from a 2x2 contingency table.

Compute the intervention strength needed to achieve a target signal reduction.

Get the severity weight (omega) for a seriousness level.

Trajectory amplification: detect accelerating reporting trends using Hill curve amplification on time-series data.

Analyze a concept through the Boundary primitive.

Analyze a concept through the Causality primitive.

Analyze two concepts through the Comparison primitive.

Analyze a concept through the Existence primitive.

Analyze a concept through the Frequency primitive.

Analyze a concept through the Irreversibility primitive.

Analyze a concept through the Location primitive.

Analyze a concept through the Mapping primitive.

Analyze a concept through the Nothing (void) primitive.

Analyze a concept through the Persistence primitive.

Analyze a concept through the Quantity primitive.

Analyze a concept through the Recursion primitive.

Analyze a concept through the Sequence primitive.

Analyze a concept through the State primitive.

Analyze a concept through the Sum (disjoint union) primitive.

Compute recommended dose given strategy and target.

Administer dose, apply decay, and optionally transition phase.

Start a new care episode at the Collect phase.

Check interaction effects between two plasma levels.

Validate and execute a phase transition.

Score episode quality on [0, 10] scale.

Cluster structured signals by structural similarity.

Correlate structural clusters with adverse event patterns to find alert candidates.

Compute summary statistics for a retrocasting training dataset.

Extract a 160-dimensional ML feature vector from a SMILES string.

Retro Signal Significance

Retro Structural Similarity

Get article abstract, metadata, and MeSH headings by PMID

Get articles that cite a given PMID (via elink citedin; limited to PMC-indexed articles)

Extract MeSH headings assigned to an article — descriptors, qualifiers, major topic flags, and chemical substances.

Find articles related to a given PMID using PubMed's similarity algorithm.

Search PubMed for articles by keyword, MeSH term, or author

Search specifically for adverse event case reports for a drug

Find pharmacovigilance signal detection papers for a drug (PRR, ROR, disproportionality, spontaneous reports)

Domain dashboard with KSB counts, regulation counts, and coverage.

Look up KSBs by ID, domain, type, or keyword.

Raw SQL query (read-only, max 100 rows).

Search regulations by text, jurisdiction, or domain.

Trace axiom → parameter → pipeline stage → Rust coverage.

Calculate Chi-square

Run one iteration of the PV control loop

Returns posterior mean, variance, 95% credible interval, and confidence score.

Returns posterior mean rate, variance, and confidence score.

Pv Core Bayesian Sequential

Returns hazard ratios, confidence intervals, and Measured confidence per coefficient.

Pv Core Cumulative Incidence

Standalone tool — works with p-values from any statistical analysis.

Wraps a single-covariate Cox model internally.

Assess all 5 IVF axioms for an intervention (ToV §35)

List the 5 IVF axioms with ToV mappings and formal statements

Greenwood SE, log-log CI, median survival, and per-point confidence scores.

significance flag, and overall confidence score.

Assess adverse event severity using Hartwig-Siegel scale (levels 1-7)

Returns the sparse TF-IDF vector, graph neighbors, and metadata.

Works for both ICH terms and free-text queries.

`pv_embedding_stats` — Index statistics for the PV embedding system.

Naranjo causality assessment

5.

Compute QBRI from benefit and risk parameters.

Derive optimal QBRI thresholds from historical FDA decisions.

Pv Qbri Equation

Returns `McpError::internal_error` if the plotters renderer fails.

Complete signal analysis with all algorithms

coincidental.

Calculate EBGM

Calculate IC

Calculate PRR

Calculate ROR

Calculate signal strength S = U × R × T (ToV Core Equation §20)

Get Chomsky classification for a PV subsystem.

Look up a T2-C composite by name.

Look up a T3 concept by pillar and name.

Pv Taxonomy Lex Symbols

Look up a T2-P primitive by name.

Get the full PV taxonomy summary (T1/T2-P/T2-C/T3 counts).

Look up cross-domain transfer confidence for a target domain.

Pv Taxonomy Transfer Matrix

Pv Taxonomy Who Pillars

WHO-UMC causality assessment

Run the Naranjo Adverse Drug Reaction Probability Scale.

Assess causality using the WHO-UMC system.

Calculate DSUR (Development Safety Update Report) data lock point and submission deadline.

Calculate PSUR/PBRER reporting interval from International Birth Date (IBD).

Calculate regulatory submission deadline from Day 0 (awareness date).

Check if a case submission was within the regulatory deadline.

Classify adverse event seriousness using ICH E2A criteria.

Determine expedited reporting type and deadline per ICH E2A/E2D and regional requirements.

List all Guardian PV Engine capabilities with their namespaces, parameter signatures, and regulatory references.

Validate ICSR against ICH E2B(R3) minimum data requirements.

Compile a PVDSL expression to bytecode and return the instruction listing.

Evaluate a PVDSL expression with optional variable bindings and return the result.

List all available PVDSL native functions organized by namespace.

Parse and validate a PVDSL expression, returning the abstract syntax tree (AST).

Compute full QBR with all available forms (simple, Bayesian, composite, therapeutic window).

Compute simple benefit-risk ratio from one benefit and one risk contingency table.

Compute therapeutic window from efficacy and toxicity Hill curve parameters.

T1 grounding: ∇ = →(Causality) + κ(Comparison) + ∂(Boundary)

Simple but effective when rankings have different scales.

`final(d) = α × dense(d) + (1-α) × normalized_sparse(d)`

Default k=60 (Cormack et al., 2009).

Rate Limit Sliding Window

Returns current state of all or specific buckets/windows.

Tokens regenerate continuously over time.

Run a single gate.

List all gate definitions.

Run full L1-L5 validation

Find PDB entries containing a given small-molecule ligand (by name or 3-letter chem component code).

Compute the binding pocket for a ligand in a PDB entry: all protein residues with any atom within a distance cutoff (default 5 Å) of any ligand atom.

Fetch full PDB structure (atom coordinates + metadata) for a given PDB ID.

Get pathways associated with a disease

Find pathways containing known drug targets

Get pathway details by stable identifier

Get molecular participants in a pathway

Search pathways by name, gene, or keyword

Search reactions by name or identifier

Search Canadian clinical trial registry

Search the Drug Product Database for Canadian market authorizations

Search licensed natural health products

Get health professional risk communications and public advisories

Get summary safety reviews (SSRs) for a drug

Search Canada Vigilance adverse reaction reports

Search Health Canada drug and health product recalls

Reddit Authenticate

Detect value signals in subreddit posts.

Get hot/trending posts from a subreddit.

Get new/recent posts from a subreddit.

Search for posts mentioning a specific entity.

Reddit Status

Get subreddit metadata.

Parse a FHIR AdverseEvent JSON and convert to a SignalInput for PV signal detection.

Batch convert multiple FHIR AdverseEvent JSONs to SignalInputs.

Parse a FHIR Bundle JSON and extract resource summaries.

Validate a FHIR resource JSON structure (checks required fields, resourceType).

Guidelines Categories

Get a specific hormone level

Guidelines Pv All

Search documents by query string

Get URL for a guideline

Get ICH guideline metadata by ID (e.g., "E2A", "Q9")

Look up an ICH/CIOMS term by name (O(1) PHF lookup + cached formatting)

Search ICH glossary terms by keyword or phrase

Ich Stats

Assess FDA effectiveness endpoint for approval pathway compatibility

Run a full code inspection audit on a file or directory.

Compare models for a specific task.

Extract primitives from regulatory source

Compare Regeneron Pharmaceuticals adverse event reporting vs a competitor using PRR from FAERS

Get recent safety labeling changes for Regeneron Pharmaceuticals products

Get Regeneron Pharmaceuticals clinical trial pipeline — active and recruiting trials by phase

Get Regeneron Pharmaceuticals approved product portfolio — brand names, generics, routes, pharmacologic classes

Get Regeneron Pharmaceuticals product recalls and enforcement actions from FDA

Get Regeneron Pharmaceuticals aggregate safety profile from FAERS — top adverse reactions, outcomes, products with most reports

Search Regeneron Pharmaceuticals products by keyword — drug name, condition, or therapeutic area

Assess all skills in the registry.

Assess a single skill's compliance tier and SMST v2 score.

Generate a gap report for the entire skill ecosystem.

Get skills eligible for promotion to a target tier.

Generate a promotion plan for a skill to reach a target tier.

Compute all 8 harm type indicators (A-H).

Check if the ecosystem is in the safe manifold.

Compute the ToV safety distance d(s) for the ecosystem.

Compare how agencies classify the same concept — seriousness criteria, causality assessment methods, expectedness definitions.

Identify mutual recognition or reliance pathways between agencies for a drug — FDA-EMA parallel review, WHO prequalification, ICH harmonized submissions.

Compare expedited reporting timelines across agencies — 15-day (FDA), 15-day (EMA), 15-day (PMDA) for fatal/life-threatening, vs 90-day periodic.

Map a regulatory action type to equivalent actions in other agencies.

Show which databases each agency maintains, reporting volumes, and data accessibility.

Translate PV terminology between agency frameworks.

Build and verify a relay chain from user-provided hops.

Get the core 4-hop detection chain (ingest → detect → threshold → alert).

Compose fidelity values multiplicatively.

Get the pre-configured 7-stage PV signal detection pipeline with verification.

Get full protein entry with function, subcellular location, and GO terms

Get disease involvement for a protein

Get protein-protein interactions

Get pharmacological data — drug binding sites and ligands

Get known sequence variants and disease associations

Search UniProt for proteins by name, gene, or organism

Deduplicates by source_id (updates existing entries).

Recent queries are cached with configurable TTL.

`retrieval_stats` — Pipeline health, cache metrics, and query analytics.

Compare Roche Holding AG adverse event reporting vs a competitor using PRR from FAERS

Get recent safety labeling changes for Roche Holding AG products

Get Roche Holding AG clinical trial pipeline — active and recruiting trials by phase

Get Roche Holding AG approved product portfolio — brand names, generics, routes, pharmacologic classes

Get Roche Holding AG product recalls and enforcement actions from FDA

Get Roche Holding AG aggregate safety profile from FAERS — top adverse reactions, outcomes, products with most reports

Search Roche Holding AG products by keyword — drug name, condition, or therapeutic area

Get Russia pharmacovigilance and ADR reports

Get Russia drug recall and withdrawal actions

Get Russia regulatory classification and approval status

Get Russia drug safety alerts and communications

Search Russia drug registration database

Rust Dev Borrow Explain

Rust Dev Cargo Bloat

Rust Dev Cargo Expand

Rust Dev Cargo Miri

Rust Dev Clippy Explain

Rust Dev Derive Advisor

Rust Dev Edition Migrate

Rust Dev Error Type

Rust Dev Invocations

Rust Dev Match Generate

Rust Dev Rustc Explain

Rust Dev Unsafe Audit

Get pharmacologic and therapeutic drug classes

Get active ingredients for a drug product

Get drug-drug interactions for a list of drugs

Get NDC codes for a drug product

Get RxNorm Concept Unique Identifier for a drug name

Search RxNorm for drugs by approximate name match

Get South Africa pharmacovigilance and ADR reports

Get South Africa drug recall and withdrawal actions

Get South Africa regulatory classification and approval status

Get South Africa drug safety alerts and communications

Search South Africa drug registration database

Compare Samsung Bioepis adverse event reporting vs a competitor using PRR from FAERS

Get recent safety labeling changes for Samsung Bioepis products

Get Samsung Bioepis clinical trial pipeline — active and recruiting trials by phase

Get Samsung Bioepis approved product portfolio — brand names, generics, routes, pharmacologic classes

Get Samsung Bioepis product recalls and enforcement actions from FDA

Get Samsung Bioepis aggregate safety profile from FAERS — top adverse reactions, outcomes, products with most reports

Search Samsung Bioepis products by keyword — drug name, condition, or therapeutic area

Compare Sanofi S.A.

Get recent safety labeling changes for Sanofi S.A.

Get Sanofi S.A.

Get Sanofi S.A.

Get Sanofi S.A.

Get Sanofi S.A.

Search Sanofi S.A.

Assess drug target druggability using multi-factor scoring — protein family, structural data, clinical precedent, genetic validation